Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Carcinogenesis. 2020 Jun 17;41(4):397-404. doi: 10.1093/carcin/bgaa013.
Pancreatic cancer is a lethal and devastating disease in the worldwide. Recognized risk factors for pancreatic cancer include cigarette smoking, obesity, type II diabetes and chronic pancreatitis. Other factors such as variant ABO blood type and Helicobacter pylori may also play an important role in pancreatic carcinogenesis. Recently, growing evidence suggests that the association between bacteria and pancreatic cancer is positive and related immune/inflammation activation and increased nitrosamine exposure may be its potential mechanism. Interestingly, it is debatable whether the relationship of bacteria and pancreatic cancer is causative, reactive or parallel and future studies are in progress. Here we review recent progress in pancreatic cancer and its related bacteria.
胰腺癌是全球范围内一种致命且具有破坏性的疾病。公认的胰腺癌危险因素包括吸烟、肥胖、Ⅱ型糖尿病和慢性胰腺炎。其他因素，如 ABO 血型变异和幽门螺杆菌，也可能在胰腺癌的发生中起重要作用。最近，越来越多的证据表明，细菌与胰腺癌之间存在正相关关系，免疫/炎症激活和亚硝胺暴露增加可能是其潜在机制。有趣的是，细菌与胰腺癌之间的关系是因果关系、反应性还是平行关系仍存在争议，未来的研究正在进行中。本文综述了胰腺癌及其相关细菌的最新研究进展。
