Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Mol Neurosci. 2020 Jun;70(6):953-958. doi: 10.1007/s12031-020-01499-7. Epub 2020 Feb 8.
Recent studies have shown contribution of long non-coding RNAs (lncRNAs) in the pathogenesis of a number of psychiatric disorders. In the current study, we investigated the association between a single nucleotide polymorphism in the lncRNA HOX transcript antisense intergenic RNA (HOTAIR) and risk of diverse neuropsychiatric conditions in Iranian population. The selected polymorphism (rs1899663) is an intronic variant of this lncRNA which has been associated with several cancers in different populations. This SNP was genotyped in 323 individuals with methamphetamine addiction, 55 children with attention-deficit hyperactive disorder (ADHD), 138 patients with bipolar disorder 1 (BPD1), 86 patients with BPD2, 53 patients with major depressive disorder (MDD), and 194 patients with schizophrenia (SCZ). There was no significant association between rs1899663 genotypes and risk of methamphetamine addiction or SCZ in any assessed inheritance model. There was a significant association between rs1899663 SNP and risk of BPD1 in allelic, co-dominant, and dominant models (P values of 0.003, 0.009, and 0.003, respectively). The T allele of this SNP conferred risk of BPD1 (OR (95% CI) = 1.70 (1.20-2.41)). This SNP was associated with risk of BPD2 in allelic and dominant models (P values of 0.02 and 0.04). The T allele of this SNP was revealed to be the risk allele for BPD2 as well (OR (95% CI) = 1.61 (1.09-2.40)). Besides, the mentioned SNP was associated with susceptibility to MDD in allelic and dominant models (P values of 0.01 and 0.03). Finally, the rs1899663 was associated with risk of ADHD in allelic, co-dominant, and dominant models (P values of 3.6E-4, 0.002, and 1.2E-4, respectively). The current investigation highlights the role of rs1899663 in conferring risk of BPD1, BPD2, MDD, and ADHD and suggests a similar underlying genetic background for these conditions.
最近的研究表明，长非编码 RNA（lncRNA）在多种精神疾病的发病机制中起作用。在本研究中，我们调查了 lncRNA HOX 转录反义基因间 RNA（HOTAIR）中的单核苷酸多态性与伊朗人群多种神经精神疾病风险之间的关联。所选的多态性（rs1899663）是该 lncRNA 的内含子变体，已在不同人群中的几种癌症中得到关联。该 SNP 在 323 名甲基苯丙胺成瘾者、55 名注意力缺陷多动障碍（ADHD）儿童、138 名双相情感障碍 1 型（BPD1）患者、86 名 BPD2 患者、53 名重度抑郁症（MDD）患者和 194 名精神分裂症（SCZ）患者中进行了基因分型。在任何评估的遗传模型中，rs1899663 基因型与甲基苯丙胺成瘾或 SCZ 的风险均无显著关联。rs1899663 SNP 与 BPD1 的风险在等位基因、共显性和显性模型中存在显著关联（P 值分别为 0.003、0.009 和 0.003）。该 SNP 的 T 等位基因增加了 BPD1 的发病风险（OR（95%CI）=1.70（1.20-2.41））。该 SNP 与 BPD2 的风险在等位基因和显性模型中相关（P 值分别为 0.02 和 0.04）。该 SNP 的 T 等位基因也被揭示为 BPD2 的风险等位基因（OR（95%CI）=1.61（1.09-2.40））。此外，该 SNP 与 MDD 的易感性在等位基因和显性模型中相关（P 值分别为 0.01 和 0.03）。最后，rs1899663 与 ADHD 的风险在等位基因、共显性和显性模型中相关（P 值分别为 3.6E-4、0.002 和 1.2E-4）。本研究强调了 rs1899663 在赋予 BPD1、BPD2、MDD 和 ADHD 风险方面的作用，并表明这些疾病具有相似的潜在遗传背景。
