Coombe Women and Infants University Hospital, Dublin, Ireland.
Royal College of Surgeons in Ireland, Dublin, Ireland.
BJOG. 2020 May;127(6):750-756. doi: 10.1111/1471-0528.16110. Epub 2020 Feb 9.
To compare the obstetric outcomes and socio-demographic factors in electronic cigarette (EC) users with cigarette smokers and non-smokers in pregnancy.
Prospective observational cohort study.
A large urban maternity hospital delivering almost 8500 infants per year.
Pregnant women attending for antenatal care.
Electronic cigarette users at time of booking history were prospectively identified. Maternal and neonatal outcomes were compared with those of pregnant smokers and non-smokers. Multiple logistic regression analysis was performed to estimate the association between the explanatory variables and birthweight.
Infant birthweight, gestation at delivery, incidence of low birthweight.
A total of 218 women with exclusive EC use and 195 women with dual use of both cigarettes and EC, had a live birth during the study period. EC users were of higher socio-economic status than smokers. Infants born to EC users had a mean birthweight of 3470 g (± 555 g), which was similar to that of non-smokers (3471 ± 504 g, P = 0.97) and significantly greater than that of smokers (3166 ± 502 g, P < 0.001). The mean birth centile of EC users was similar to non-smokers (51st centile versus 47th centile, P = 0.28) and significantly greater than that of smokers (27th centile, P < 0.001). Dual users had a mean birthweight and birth centile similar to that of smokers.
The birthweight of infants born to EC users is similar to that of non-smokers, and significantly greater than cigarette smokers. Dual users of both cigarettes and EC have a birthweight similar to that of smokers.
Birthweight of infants born to electronic cigarette users appears to be similar to that of non-smokers.
比较电子香烟（EC）使用者、吸烟者和非吸烟者在妊娠期间的产科结局和社会人口学因素。
前瞻性观察队列研究。
一家每年接生近 8500 名婴儿的大型城市妇产医院。
参加产前保健的孕妇。
在预约时前瞻性地确定使用 EC 的孕妇。将母婴结局与吸烟孕妇和不吸烟孕妇进行比较。采用多因素逻辑回归分析估计解释变量与出生体重之间的关系。
婴儿出生体重、分娩时的胎龄、低出生体重的发生率。
在研究期间，共有 218 名单纯 EC 使用者和 195 名同时使用香烟和 EC 的双重使用者分娩活产儿。EC 使用者的社会经济地位高于吸烟者。EC 使用者的婴儿出生体重平均为 3470g（±555g），与不吸烟者（3471±504g，P=0.97）相似，明显大于吸烟者（3166±502g，P<0.001）。EC 使用者的出生体重中位数与不吸烟者相似（第 51 个百分位数与第 47 个百分位数，P=0.28），明显大于吸烟者（第 27 个百分位数，P<0.001）。双重使用者的出生体重和出生体重中位数与吸烟者相似。
EC 使用者的婴儿出生体重与不吸烟者相似，明显大于吸烟者。香烟和 EC 的双重使用者的出生体重与吸烟者相似。
EC 使用者的婴儿出生体重似乎与不吸烟者相似。
