Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile.
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chil.
Food Res Int. 2020 Mar;129:108843. doi: 10.1016/j.foodres.2019.108843. Epub 2019 Dec 3.
The formation of advanced glycation end-products (AGEs) is a key pathophysiological event linked not only to the onset and progression of diabetic complications, but also to neurodegeneration, cardiovascular diseases, cancer, and others important human diseases. AGEs contributions to pathophysiology are mainly through the formation of cross-links and by engaging the receptor for advanced glycation end-products (RAGE). Polyphenols are secondary metabolites found largely in fruits, vegetables, cereals, and beverages, and during many years, important efforts have been made to elucidate their beneficial effects on human health, mainly ascribed to their antioxidant activities. In the present review, we highlighted the beneficial actions of polyphenols aimed to diminish the harmful consequences of advanced glycation, mainly by the inhibition of ROS formation during glycation, the inhibition of Schiff base, Amadori products, and subsequent dicarbonyls group formation, the activation of the glyoxalase system, as well as by blocking either AGEs-RAGE interaction or cell signaling.
晚期糖基化终产物（AGEs）的形成是一个关键的病理生理事件，不仅与糖尿病并发症的发生和进展有关，而且与神经退行性变、心血管疾病、癌症等重要人类疾病有关。AGEs 对病理生理学的贡献主要是通过形成交联和结合晚期糖基化终产物受体（RAGE）。多酚是在水果、蔬菜、谷物和饮料中大量发现的次生代谢物，多年来，人们做出了重要努力来阐明它们对人类健康的有益作用，主要归因于它们的抗氧化活性。在本综述中，我们强调了多酚的有益作用，旨在减少晚期糖基化的有害后果，主要是通过抑制糖化过程中的 ROS 形成、抑制席夫碱、艾杜糖醛酸产物和随后的二羰基基团形成、激活甘油醛酶系统，以及通过阻断 AGEs-RAGE 相互作用或细胞信号转导。
