Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.
Curr Med Chem. 2021;28(2):213-237. doi: 10.2174/0929867327666200210144847.
Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the "phytocomplex" of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile.
大麻二酚（CBD）是一种非精神活性植物大麻素，它是大麻“植物复合物”的成分之一。自从以 CBD 为基础的药物和商业产品上市以来，这种天然化合物引起了越来越多的兴趣。这篇综述旨在全面探讨为分离和定量 CBD 而开发的提取和分析方法。本文批判性地审查了最新的尖端技术，从产量、灵敏度、灵活性和总体性能等方面进行了评估，并与原始代表性结果一起进行了回顾。除了目前文献中可用的贡献外，还讨论了 CBD 的新型高效合成方法的最新进展，这一方法对制药行业很有吸引力。此外，鉴于 CBD 的治疗潜力日益受到关注，而对正在进行的生化途径的理解有限，读者将了解到关于 CBD 对多种不同靶点的分子相互作用的最新计算机研究，试图填补这一空白。从文献中检索到的计算数据与新的计算机实验相结合，进行了批判性讨论，为 CBD 的不可争议的潜力及其治疗概况提供了全面和最新的概述。
