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特定年龄段的抑郁症患者肠道微生物群落组成的差异变化。

Age-specific differential changes on gut microbiota composition in patients with major depressive disorder.

机构信息

Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China.

Chongqing Key Laboratory of Cerebral Vascular Disease Research, Chongqing Medical University, Chongqing 400016, China.

出版信息

Aging (Albany NY). 2020 Feb 10;12(3):2764-2776. doi: 10.18632/aging.102775.

DOI:10.18632/aging.102775
PMID:32040443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7041727/
Abstract

Emerging evidence has shown the age-related changes in gut microbiota, but few studies were conducted to explore the effects of age on the gut microbiota in patients with major depressive disorder (MDD). This study was performed to identify the age-specific differential gut microbiota in MDD patients. In total, 70 MDD patients and 71 healthy controls (HCs) were recruited and divided into two groups: young group (age 18-29 years) and middle-aged group (age 30-59 years). The 16S rRNA gene sequences were extracted from the collected fecal samples. Finally, we found that the relative abundances of and were significantly decreased and increased, respectively, in young MDD patients as compared with young HCs, and the relative abundances of and were significantly decreased and increased, respectively, in middle-aged MDD patients as compared with middle-aged HCs. Meanwhile, six and 25 differentially abundant bacterial taxa responsible for the differences between MDD patients (young and middle-aged, respectively) and their respective HCs were identified. Our results demonstrated that there were age-specific differential changes on gut microbiota composition in patients with MDD. Our findings would provide a novel perspective to uncover the pathogenesis underlying MDD.

摘要

新出现的证据表明，肠道微生物群随着年龄的变化而变化，但很少有研究探讨年龄对重度抑郁症（MDD）患者肠道微生物群的影响。本研究旨在确定 MDD 患者中特定于年龄的肠道微生物群差异。共招募了 70 名 MDD 患者和 71 名健康对照者（HCs），并将其分为两组：年轻组（18-29 岁）和中年组（30-59 岁）。从收集的粪便样本中提取 16S rRNA 基因序列。最后，我们发现与年轻 HCs 相比，年轻 MDD 患者的 和 相对丰度显著降低，而 和 相对丰度显著降低；与中年 HCs 相比，中年 MDD 患者的 和 相对丰度显著降低。同时，确定了 6 个和 25 个负责 MDD 患者（年轻和中年）与其各自 HCs 之间差异的差异丰富细菌分类群。我们的研究结果表明，MDD 患者的肠道微生物群组成存在特定于年龄的差异变化。我们的研究结果为揭示 MDD 的发病机制提供了新的视角。

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