Department of Oral Surgery, Faculty of Medicine, University of Banja Luka Save Mrkalja 14, 78000 Banja Luka, Bosnia and Herzegovina
Med Oral Patol Oral Cir Bucal. 2020 Mar 1;25(2):e154-e160. doi: 10.4317/medoral.23061.
Hyaluronic acid is widely used in the medical field. However, there is a lack of research about its effect on patients with certain risks, such as compromised wound healing commonly found in patients with poorly controlled type 2 diabetes. The aim of this study is to investigate the efficacy of hyaluronic acid on the post-extraction wound healing and pain in patients with poorly controlled type 2 diabetes.
The randomized controlled split-mouth study was designed, which included 30 patients with poorly controlled type 2 diabetes with a bilaterally same teeth in the lower jaw for extraction. The sockets treated with 0.8% hyaluronic acid represented the study group, while the sockets where hyaluronic acid was not applied represented the control group. Wound closure rate (WCR), clinical scores in wound healing scale (WHS) and pain intensity in Visual analogue scale (VAS) were recorded. Patients were followed up on 5th, 10th, 15th, 20th, 25th day after tooth extraction.
The results showed a higher WCR at the extraction site where hyaluronic acid was applied. Also, statistically significant difference was found (p< 0.001). In regards to WHS, the sockets treated with hyaluronic acid showed better healing, especially on day 10 (p=0.006) and day 15 (p=0.021). However, there were no statistically significant differences in VAS scores between groups.
Hyaluronic acid placed in post-extraction socket in patients with poorly controlled diabetes may improve wound healing, especially in the first days after application.
透明质酸在医学领域得到广泛应用。然而，对于某些风险患者（如 2 型糖尿病控制不佳的患者常见的伤口愈合受损），其疗效的研究较少。本研究旨在探讨透明质酸对 2 型糖尿病控制不佳患者拔牙后伤口愈合和疼痛的疗效。
设计了一项随机对照的分口研究，纳入 30 例下颌双侧相同牙齿需要拔牙的 2 型糖尿病控制不佳的患者。用 0.8%透明质酸处理的拔牙窝为观察组，未应用透明质酸的拔牙窝为对照组。记录伤口闭合率（WCR）、伤口愈合评分量表（WHS）的临床评分和视觉模拟评分（VAS）的疼痛强度。患者在拔牙后第 5、10、15、20、25 天进行随访。
结果显示，应用透明质酸的拔牙部位 WCR 更高，差异具有统计学意义（p<0.001）。在 WHS 方面，应用透明质酸的拔牙窝愈合更好，特别是在第 10 天（p=0.006）和第 15 天（p=0.021）。然而，两组 VAS 评分差异无统计学意义。
将透明质酸置于 2 型糖尿病控制不佳患者拔牙后的拔牙窝中，可能会改善伤口愈合，尤其是在应用后的最初几天。
