2000 年至 2018 年中国大陆猪源大肠杆菌对氯霉素耐药性的流行情况：系统评价和荟萃分析。
The prevalence of amphenicol resistance in Escherichia coli isolated from pigs in mainland China from 2000 to 2018: A systematic review and meta-analysis.
机构信息
Lab of Medical Microbiology Engineering, College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
出版信息
PLoS One. 2020 Feb 11;15(2):e0228388. doi: 10.1371/journal.pone.0228388. eCollection 2020.
BACKGROUND
Amphenicols have been widely used in the pig industry in China, leading to varying degrees of drug resistance.
METHODS
The systematic review was performed according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analysis) recommendations on studies investigating the prevalence of amphenicol-resistant Escherichia coli (E. coli) isolated from pig in mainland China from 2000 to 2018, a random-effects model was selected, then followed by meta-analysis.
RESULTS
A total of 103 articles were included in the study. The results of the meta-analysis revealed that the pooled summarized prevalence of resistance to chloramphenicol (CAP) was 72.31% (95% confidence interval (95% CI) = 67.12%-77.23%) and to florfenicol (FF) was 58.64% (95% CI = 52.48%-64.67%). During the past 18 years, the resistance rate to CAP remained high initially but then declined rapidly after 2012, whereas the resistance rate to FF plateaued (54.13%-59.60%) from 2000-2018. In different parts of China, the rate of resistance to amphenicols among E. coli isolates was fairly consistent, with the exception of the north and northwest regions.
CONCLUSIONS
In 2002, the veterinary use of CAP was prohibited and its resistance levels in E. coli isolated from pigs was initially maintained at a high level but then showed an obvious downward trend in recent years. Resistance to commonly used FF remained at a high but stable level.
背景
安普霉素在中国的养猪业中被广泛应用，导致了不同程度的耐药性。
方法
根据 PRISMA（系统评价和荟萃分析报告的首选条目）建议，对 2000 年至 2018 年间中国大陆分离的猪源大肠杆菌（E. coli）对安普霉素耐药性的研究进行了系统评价，选择了随机效应模型，然后进行了荟萃分析。
结果
共有 103 篇文章纳入研究。荟萃分析结果显示，氯霉素（CAP）耐药的汇总流行率为 72.31%（95%置信区间[95%CI]：67.12%-77.23%），氟苯尼考（FF）耐药的汇总流行率为 58.64%（95%CI=52.48%-64.67%）。在过去的 18 年中，CAP 的耐药率最初较高，但在 2012 年后迅速下降，而 FF 的耐药率则从 2000 年到 2018 年保持在较高水平（54.13%-59.60%）。在中国不同地区，除了北部和西北部地区外，大肠杆菌对安普霉素的耐药率相当一致。
结论
2002 年，兽医禁用 CAP，其对猪源大肠杆菌的耐药水平最初维持在较高水平，但近年来呈明显下降趋势。对常用的 FF 的耐药性仍处于较高但稳定的水平。
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