发酵豆粕可改善成人食用豆饼后异黄酮的代谢。

Fermentation of soybean meal improves isoflavone metabolism after soy biscuit consumption by adults.

机构信息

Laboratório de Bioquímica Nutricional e de Alimentos, Department of Biochemistry, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Laboratório de Desenvolvimento e Análise Sensorial de Alimentos, Department of Natural Products and Food, Pharmacy Faculty, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

J Sci Food Agric. 2020 May;100(7):2991-2998. doi: 10.1002/jsfa.10328. Epub 2020 Mar 10.

DOI:10.1002/jsfa.10328

PMID:32048288

Abstract

BACKGROUND

Urinary excretion of isoflavones and their metabolites after the consumption of soybean meal (SBM) and fermented soybean meal (FSBM) biscuits was investigated in humans in a randomized double-blinded crossover clinical trial.

RESULTS

Aglycones were the most abundant metabolites in urine in both treatments. After FSBM consumption, total urinary excretion of aglycones and metabolites was 54% higher when compared to SBM biscuits. All metabolites were more rapidly excreted after FSBM biscuit consumption when compared to SBM biscuits. Urinary recovery of isoflavones was higher after FSBM biscuit consumption, reaching 67%. Women excreted higher amounts of colonic metabolites and lower amounts of aglycones than men. The prevalence of O-demethylangolensin-producer, equol-producer and nonproducer metabotypes was 56%, 11% and 36% after SBM consumption and 72%, 11% and 17% after FSBM consumption, respectively.

CONCLUSIONS

Together, our findings indicate that fermentation improves isoflavone bioavailability and possibly reduces the impact of gut microbiota on the metabolism of isoflavones. © 2020 Society of Chemical Industry.

摘要

背景

在一项随机双盲交叉临床试验中，研究了人类食用大豆粉（SBM）和发酵大豆粉（FSBM）饼干后尿液中异黄酮及其代谢物的排泄情况。

结果

在两种处理中，糖苷配基都是尿液中最丰富的代谢物。与 SBM 饼干相比，FSBM 饼干消费后糖苷配基和代谢物的总尿排泄量增加了 54%。与 SBM 饼干相比，所有代谢物在 FSBM 饼干消费后都更快地排泄。FSBM 饼干消费后异黄酮的尿回收率更高，达到 67%。女性比男性排泄更多的结肠代谢物和更少的糖苷配基。SBM 消费后，O-去甲基安哥拉辛-原生成代谢型、大豆苷元生成代谢型和非生成代谢型的流行率分别为 56%、11%和 36%，FSBM 消费后分别为 72%、11%和 17%。