Massachusetts General Hospital Center for Cancer Research, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Cancer Cell. 2020 Feb 10;37(2):145-146. doi: 10.1016/j.ccell.2020.01.008.
For decades, scientists have observed small extrachromosomal DNA fragments in tumor cells, yet comprehensive examination of their structure and function has remained difficult. Three recent studies, published in Nature, Cell, and Nature Genetics, have now shed important light on the architecture, regulatory capacity, and oncogenic nature of tumor-associated extrachromosomal DNA.
几十年来，科学家们一直在观察肿瘤细胞中的小型染色体外 DNA 片段，但对其结构和功能的全面研究一直很困难。最近发表在《自然》《细胞》和《自然遗传学》上的三项研究，现在已经阐明了肿瘤相关染色体外 DNA 的结构、调控能力和致癌性质。
