School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.
School of Pharmaceutical Science, Binzhou Medical University, Yantai 264003, People's Republic of China.
Bioorg Chem. 2020 Mar;96:103651. doi: 10.1016/j.bioorg.2020.103651. Epub 2020 Feb 4.
Eight labdane diterpenoids, including two new labdane diterpenoids, named forsyshiyanins A-B (2-3), along with six known ones (1, 4-8), were isolated from the fruits of Forsythia suspensa. The new structures including their absolute configurations were elucidated by extensive spectroscopic analyses, X-ray diffraction and computational calculation. In vitro, eight labdane diterpenoids showed anti-inflammatory activities, with the inhibition rates of release of β-glucuronidase from polymorphonuclear leukocytes of rats being in the range 46.8-51.0% at concentrations of 10 µM, as well as anti-viral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV), with the IC values in the range 18.4-26.2 μM and EC values in the range 10.5-14.4 μM, respectively.
从连翘果实中分离得到了 8 个拉伯烷二萜类化合物，包括 2 个新的拉伯烷二萜类化合物，命名为forsyshiyanin A-B（2-3），以及 6 个已知化合物（1、4-8）。通过广泛的光谱分析、X 射线衍射和计算计算，阐明了新结构及其绝对构型。在体外，8 个拉伯烷二萜类化合物表现出抗炎活性，在 10 μM 浓度下，对大鼠多形核白细胞β-葡糖苷酸酶释放的抑制率在 46.8-51.0%范围内，并且对甲型流感（H1N1）病毒和呼吸道合胞病毒（RSV）具有抗病毒活性，IC 值范围为 18.4-26.2 μM，EC 值范围为 10.5-14.4 μM。
