School of Pharmaceutical Science, Yantai University, Yantai, 264005, P. R. China.
College of Life Sciences, Yantai University, Yantai, 264005, P. R. China.
Chem Biodivers. 2022 Jan;19(1):e202100668. doi: 10.1002/cbdv.202100668. Epub 2021 Dec 29.
Forsyqinlingines C (1) and D (2), two C -monoterpenoid alkaloids bearing a rare skeleton, were isolated from the ripe fruits of Forsythia suspensa. Their structures, including absolute configurations, were fully elucidated by extensive spectroscopic data and ECD experiments. The plausible biogenetic pathway for compounds 1 and 2 was also proposed. In vitro, two C -monoterpenoid alkaloids showed anti-inflammatory activity performed by the inhibitory effect on the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs), as well as antiviral activity against influenza A (H1N1) virus and respiratory syncytial virus (RSV).
连翘酯苷 C（1）和 D（2）是从连翘成熟果实中分离得到的两个具有罕见骨架的 C-单萜生物碱。通过广泛的光谱数据和 ECD 实验，阐明了它们的结构，包括绝对构型。还提出了化合物 1 和 2 的可能生物合成途径。体外实验表明，两种 C-单萜生物碱具有抗炎活性，通过抑制大鼠多形核白细胞（PMNs）β-葡糖苷酸酶的释放来发挥作用，同时还具有抗甲型流感（H1N1）病毒和呼吸道合胞病毒（RSV）的活性。
