School of Pharmaceutical Science, Yantai University, Yantai, 264005, People's Republic of China.
School of Pharmaceutical Science, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Phytochemistry. 2020 May;173:112298. doi: 10.1016/j.phytochem.2020.112298. Epub 2020 Mar 5.
Five previously undescribed labdane diterpenoids, named Forsypensins A-E, were isolated from the fruits of Forsythia suspensa. The structures and relative configurations of the compounds were elucidated via extensive spectroscopic methods, and their absolute configurations were fully confirmed by single crystal X-ray diffraction analyses using Cu Kα radiation and electronic circular dichroism data. The five labdane diterpenoids showed in vitro anti-inflammatory activity in rat polymorphonuclear leukocytes, inhibiting the rates of β-glucuronidase release by 43.6%-49.2% at concentrations of 10 μM. The compounds also had anti-viral activity against influenza A (H1N1) virus and respiratory syncytial virus (RSV), with IC values in the range 21.8-27.4 μM, and EC values in the range 10.5-15.4 μM, respectively.
从连翘果实中分离得到了五个以前未描述过的角鲨烷二萜类化合物，命名为 Forsypensins A-E。通过广泛的光谱方法阐明了化合物的结构和相对构型，并通过使用 Cu Kα 辐射和电子圆二色性数据的单晶 X 射线衍射分析完全确定了它们的绝对构型。这五个角鲨烷二萜类化合物在体外对大鼠多形核白细胞表现出抗炎活性，在 10 μM 浓度下抑制β-葡糖醛酸酶释放的率为 43.6%-49.2%。这些化合物还对甲型流感（H1N1）病毒和呼吸道合胞病毒（RSV）具有抗病毒活性，IC 值范围为 21.8-27.4 μM，EC 值范围为 10.5-15.4 μM。
