Department of Speech Language Pathology, School of Public Health, Honam University, 417, Eodeung-daero, Gwangsan-gu, Gwangju 62399, Korea.
Int J Environ Res Public Health. 2020 Feb 9;17(3):1095. doi: 10.3390/ijerph17031095.
: This study aimed to conduct a qualitative evaluation by synthesizing previous studies on the effect of transcranial direct current stimulation (tDCS) on primary progressive aphasia (PPA)'s naming ability and prove the effects of tDCS mediation on PPA naming using meta-analysis. : This study searched literature published from January 2000 to July 2019 using four academic databases (i.e., PubMed, Web of Science, MEDLINE, and Cochrane Library). The final seven publications were systematically evaluated and meta-analysis was conducted for two papers. The effect size was estimated by a standard mean difference (SMD) using Hedge's g, and the significance of effect size was confirmed using the 95% confidence interval. : The results of seven previous studies' quality assessments ranged from 15 to 26, which were rated above adequate. The results of the meta-analysis showed that the effect size was 0.82 (95% CI: 0.16-1.47), which was a significant 'large effect'. : This meta-analysis proved that tDCS intervention significantly improved the naming performance of PPA. Future studies must confirm the effects of tDCS on naming intervention by using meta-analysis including many RCT studies.
本研究旨在通过综合先前关于经颅直流电刺激（tDCS）对原发性进行性失语症（PPA）命名能力影响的研究，进行定性评估，并通过荟萃分析证明 tDCS 对 PPA 命名的中介作用。本研究使用四个学术数据库（即 PubMed、Web of Science、MEDLINE 和 Cochrane Library），从 2000 年 1 月至 2019 年 7 月检索文献。对最后 7 篇出版物进行系统评价，并对 2 篇论文进行荟萃分析。使用 Hedge's g 估计标准均数差（SMD）作为效应量，并使用 95%置信区间确认效应量的显著性。7 项先前研究的质量评估结果范围为 15 至 26，被评为足够高。荟萃分析结果表明，效应量为 0.82（95%CI：0.16-1.47），为显著的“大效应”。本荟萃分析证明 tDCS 干预可显著改善 PPA 的命名表现。未来的研究必须通过包括许多 RCT 研究的荟萃分析，来确认 tDCS 对命名干预的效果。
