Jerônimo Laura Silva, Abreu Lucas Guimarães, Cunha Fabiano Araújo, Esteves Lima Rafael Paschoal
Oral Health Prev Dent. 2020 Feb 14;18(1):11-17. doi: 10.3290/j.ohpd.a44114.
To assess the relationship between periodontitis and nosocomial pneumonia in intensive care unit (ICU) patients.
The present study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered (CRD42018105124) with PROSPERO (International prospective register for systematic reviews, University of York, York, UK). A search was conducted in five databases without restrictions regarding language or date of publication. From 560 studies selected, 10 underwent full-text analysis. Five studies were eligible (five case-control studies), and all were entered in the meta-analysis. Meta-analysis was performed with tests for sensitivity and statistical heterogeneity. Summary effect measures were calculated by odds ratio (OR) and 95% confidence interval (CI).
There was a significant association between periodontitis and nosocomial pneumonia in the meta-analysis (OR 2.55, 95% CI 1.68 to 3.86). In this meta-analysis, I2 = 0%.
The evidence demonstrates a positive association between periodontitis and nosocomial pneumonia. Individuals with periodontitis admitted to the ICU were more likely to present nosocomial pneumonia than individuals without periodontitis.
评估重症监护病房（ICU）患者牙周炎与医院获得性肺炎之间的关系。
本研究按照系统评价和Meta分析的首选报告项目（PRISMA）声明的指南进行，并在国际前瞻性系统评价注册库（PROSPERO，英国约克大学）注册（注册号：CRD42018105124）。在五个数据库中进行检索，对语言和发表日期无限制。从筛选出的560项研究中，10项进行了全文分析。5项研究符合条件（5项病例对照研究），全部纳入Meta分析。采用敏感性检验和统计学异质性检验进行Meta分析。通过比值比（OR）和95%置信区间（CI）计算汇总效应量。
Meta分析显示牙周炎与医院获得性肺炎之间存在显著关联（OR 2.55，95%CI 1.68至3.86）。在此Meta分析中，I2 = 0%。
证据表明牙周炎与医院获得性肺炎呈正相关。入住ICU的牙周炎患者比无牙周炎患者更易发生医院获得性肺炎。
