食管鳞癌原位异种移植小鼠模型。

Orthotopic Xenograft Mouse Model in Esophageal Squamous Cell Carcinoma.

机构信息

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Vium Inc., San Mateo, CA, USA.

出版信息

Methods Mol Biol. 2020;2129:149-160. doi: 10.1007/978-1-0716-0377-2_12.

DOI:10.1007/978-1-0716-0377-2_12

PMID:32056176

Abstract

Orthotopic xenograft model recapitulates the faithful organ-specific microenvironment and facilitates analyses involving tumor-stromal interactions that are crucial for developing new-generation cancer therapy. Herein, we describe the detailed rationales and protocols of a versatile orthotopic xenograft model for esophageal squamous cell carcinoma.

摘要

原位异种移植模型再现了忠实的器官特异性微环境，并促进了涉及肿瘤-基质相互作用的分析，这对于开发新一代癌症治疗方法至关重要。本文详细描述了一种用于食管鳞癌的多功能原位异种移植模型的基本原理和方案。