Khadra Dima, Itani Leila, Chebaro Yomna, Obeid May, Jaber Miryam, Ghanem Reham, Ayton Agnes, Kreidieh Dima, E Masri Dana, Kimura Akira, Tannir Hana, El Ghoch Marwan
Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, P.O. Box 11-5020 Riad El Solh, Beirut, Lebanon.
University of Oxford, Consultant Psychiatrist, Warneford Hospital, Oxford OX3 7JX, United Kingdom.
Curr Cardiol Rev. 2020;16(2):153-162. doi: 10.2174/1573403X16666200214104122.
In the last two decades, a new phenotype termed Sarcopenic Obesity (SO), in which sarcopenia and obesity coexist, has emerged.
The aim of this systematic review and meta-analysis was first to assess the prevalence of Metabolic syndrome (Mets) among individuals with and without SO, and second, to determine if SO may increase the relative risk of Mets.
This study was conducted in adherence to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and the data were collated by means of metaanalysis and narrative synthesis.
Twelve studies including a total of 11,308 adults with overweight or obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, a similar overall prevalence of Mets in individuals with SO (61.49%; 95% CI: 52.19-70.40) when compared to those without SO (56.74%; 95% CI: 47.32-65.93) was identified. Second, the presence of SO appears not to increase the risk of Mets with respect to those without SO (RR = 1.08, 95% CI: 0.99- 1.17, p = 0.07).
No higher prevalence of Mets among individuals with SO when compared to those with obesity only, nor a significant association between SO and a higher risk of Mets was found.
在过去二十年中，一种新的表型——肌少症性肥胖（SO）出现了，即肌少症和肥胖并存。
本系统评价和荟萃分析的目的，一是评估有无SO个体中代谢综合征（Mets）的患病率，二是确定SO是否会增加Mets的相对风险。
本研究按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行，数据通过荟萃分析和叙述性综合进行整理。
12项研究共纳入11308名超重或肥胖的成年男女，符合纳入标准并进行了综述，得出两个主要结果。第一，与无SO者（56.74%；95%CI：47.32 - 65.93）相比，SO个体中Mets的总体患病率相似（61.49%；95%CI：52.19 - 70.40）。第二，与无SO者相比，SO的存在似乎不会增加Mets的风险（RR = 1.08，95%CI：0.99 - 1.17，p = 0.07）。
与仅患有肥胖症的个体相比，SO个体中Mets的患病率没有更高，且未发现SO与更高的Mets风险之间存在显著关联。
