Jiao Wei-Hua, Xu Qi-Hang, Ge Guang-Bo, Shang Ru-Yi, Zhu Hong-Rui, Liu Hong-Yan, Cui Jie, Sun Fan, Lin Hou-Wen
Research Centre for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Org Lett. 2020 Mar 6;22(5):1825-1829. doi: 10.1021/acs.orglett.0c00150. Epub 2020 Feb 14.
Three unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides A-C (-), were isolated from a strain of marine sponge symbiotic fungus 164013. Their structures were determined by spectroscopic data analysis, and absolute configurations were assigned by single-crystal X-ray diffraction with ECD spectral analysis. Flavipesides A-C showed potent pancreatic lipase (PL) inhibitory activity with IC values of 0.07-0.23 μM.
从一株海洋海绵共生真菌164013中分离出三种不同寻常的氯化聚酮合酶-非核糖体肽合成酶（PKS-NRPS）杂合代谢产物，即黄柄菌素A-C（-）。通过光谱数据分析确定了它们的结构，并通过单晶X射线衍射结合电子圆二色光谱（ECD）分析确定了绝对构型。黄柄菌素A-C表现出较强的胰脂肪酶（PL）抑制活性，IC值为0.07-0.23μM。
