孕期及产后使用大麻的情况。
Cannabis use during pregnancy and postpartum.
作者信息
Badowski Sophia, Smith Graeme
机构信息
Resident in obstetrics and gynecology at Queen's University in Kingston, Ont.
Maternal-fetal medicine specialist and Professor and Head of the Department of Obstetrics and Gynaecology at Queen's University.
出版信息
Can Fam Physician. 2020 Feb;66(2):98-103.
Abstract
OBJECTIVE
To help obstetric care providers, including family physicians, nurse practitioners, midwives, and obstetricians, educate patients on the risks of cannabis use in pregnancy and postpartum and its relationship to nausea and vomiting in pregnancy.
SOURCES OF INFORMATION
The Ovid MEDLINE database was searched using the MeSH terms and in various combinations. The relevant articles were reviewed and further sources were found within the references of these articles.
MAIN MESSAGE
In utero exposure to cannabis has been associated with long-term neurodevelopmental outcomes that persist into young adulthood. Cannabis should not be used to treat nausea and vomiting in pregnancy and its chronic use might lead to the development of cannabinoid hyperemesis syndrome.
CONCLUSION
There is no known safe level of cannabis use during pregnancy or lactation. Pregnant women should be counseled regarding the risks of in utero exposure and encouraged to abstain from use in pregnancy and while breastfeeding.
摘要
目的
帮助产科护理人员，包括家庭医生、执业护士、助产士和产科医生，就孕期和产后使用大麻的风险及其与孕期恶心和呕吐的关系对患者进行教育。
信息来源
使用医学主题词以各种组合方式检索了Ovid MEDLINE数据库。对相关文章进行了综述，并在这些文章的参考文献中找到了更多来源。
主要信息
子宫内接触大麻与持续至青年期的长期神经发育结果有关。大麻不应被用于治疗孕期恶心和呕吐，长期使用可能导致大麻素 hyperemesis 综合征的发生。
结论
孕期或哺乳期使用大麻不存在已知的安全水平。应向孕妇咨询子宫内接触大麻的风险，并鼓励她们在孕期和哺乳期避免使用。
相似文献
1
Cannabis use during pregnancy and postpartum.孕期及产后使用大麻的情况。
Can Fam Physician. 2020 Feb;66(2):98-103.
2
Marijuana Use in Pregnancy: Concerns in an Evolving Era.孕期使用大麻：不断发展的时代中的担忧
J Midwifery Womens Health. 2017 May;62(3):363-367. doi: 10.1111/jmwh.12631. Epub 2017 May 12.
3
Cannabis and synaptic reprogramming of the developing brain.大麻与发育中大脑的突触重编程。
Nat Rev Neurosci. 2021 Jul;22(7):423-438. doi: 10.1038/s41583-021-00465-5. Epub 2021 May 21.
4
Cannabis Use During the Perinatal Period in a State With Legalized Recreational and Medical Marijuana: The Association Between Maternal Characteristics, Breastfeeding Patterns, and Neonatal Outcomes.在一个娱乐和医用大麻合法化的州，围产期大麻使用情况：产妇特征、母乳喂养模式与新生儿结局之间的关联。
J Pediatr. 2018 Jun;197:90-96. doi: 10.1016/j.jpeds.2018.02.005. Epub 2018 Mar 28.
5
Cannabis Use During Lactation: Literature Review and Clinical Recommendations.哺乳期使用大麻：文献综述与临床建议
J Obstet Gynaecol Can. 2020 Oct;42(10):1248-1253. doi: 10.1016/j.jogc.2019.11.003. Epub 2020 Jan 25.
6
Addressing cannabis consumption among patients with hyperemesis gravidarum.解决妊娠剧吐患者的大麻消费问题。
AJOG Glob Rep. 2023 Feb 14;3(2):100180. doi: 10.1016/j.xagr.2023.100180. eCollection 2023 May.
7
Cannabinoid hyperemesis syndrome: a cause of refractory nausea and vomiting in pregnancy.大麻素呕吐综合征：妊娠期难治性恶心和呕吐的一个病因。
Obstet Gynecol. 2015 Jun;125(6):1484-1486. doi: 10.1097/AOG.0000000000000595.
8
Guideline No. 425b: Cannabis Use Throughout Women's Lifespans - Part 2: Pregnancy, the Postnatal Period, and Breastfeeding.指南 425b：女性一生的大麻使用情况 - 第 2 部分：怀孕、产后和哺乳期。
J Obstet Gynaecol Can. 2022 Apr;44(4):436-444.e1. doi: 10.1016/j.jogc.2022.01.013.
9
[Short- and long-term consequences of prenatal exposure to cannabis].[产前接触大麻的短期和长期后果]
J Gynecol Obstet Biol Reprod (Paris). 2006 Feb;35(1):62-70. doi: 10.1016/s0368-2315(06)76373-6.
10
Cannabinoid hyperemesis syndrome: an underreported entity causing nausea and vomiting of pregnancy.大麻素呕吐综合征：一种被低估的导致妊娠恶心和呕吐的实体。
Arch Gynecol Obstet. 2011 Nov;284(5):1095-7. doi: 10.1007/s00404-010-1811-8. Epub 2010 Dec 18.
引用本文的文献
1
Hyperemesis in Pregnancy: Complications and Treatment.妊娠剧吐：并发症与治疗
Med Sci (Basel). 2025 Aug 14;13(3):132. doi: 10.3390/medsci13030132.
2
Association Between Prenatal Cannabis Exposure and Child Health Care Use: A Retrospective Cohort Study in Ontario, Canada.产前接触大麻与儿童医疗保健使用之间的关联：加拿大安大略省的一项回顾性队列研究。
J Pediatr Clin Pract. 2025 Jun 2;17:200151. doi: 10.1016/j.jpedcp.2025.200151. eCollection 2025 Sep.
3
Pregnancy Care in Times of Cannabis Legalization: Self-Rated Knowledge, Risk Perception and Communication Practices of Midwives in Germany.大麻合法化时代的孕期护理：德国助产士的自我评估知识、风险认知与沟通实践
Healthcare (Basel). 2025 May 23;13(11):1228. doi: 10.3390/healthcare13111228.
4
Cannabis and Dermatological Implications: A Traditional Review of Adverse Cutaneous Reactions and Systemic Risks.大麻与皮肤学影响：不良皮肤反应和全身风险的传统综述
Cureus. 2025 Apr 21;17(4):e82711. doi: 10.7759/cureus.82711. eCollection 2025 Apr.
5
Racial Equity in Urine Drug Screening Policies in Labor and Delivery.分娩期间尿液药物筛查政策中的种族平等
JAMA Netw Open. 2025 Mar 3;8(3):e250908. doi: 10.1001/jamanetworkopen.2025.0908.
6
Receptiveness to participating in cannabis research in pregnancy: a survey study at The Ottawa Hospital.孕期参与大麻研究的接受度：渥太华医院的一项调查研究
F1000Res. 2021 May 24;10:413. doi: 10.12688/f1000research.51947.1. eCollection 2021.
7
Evaluation of the Association Between Prenatal Cannabis Use and Risk of Developmental Delay.孕期使用大麻与发育迟缓风险之间关联的评估。
JAACAP Open. 2024 May 24;2(4):250-262. doi: 10.1016/j.jaacop.2024.03.004. eCollection 2024 Dec.
8
Tobacco Smoke Exposure and Lactation.接触烟草烟雾与哺乳
Cureus. 2024 Nov 13;16(11):e73651. doi: 10.7759/cureus.73651. eCollection 2024 Nov.
9
Effects of in utero exposure to Δ-9-tetrahydrocannabinol on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques.子宫内暴露于 Δ-9-四氢大麻酚对食蟹猴心脏细胞外基质表达和血管转录组的影响。
Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H701-H714. doi: 10.1152/ajpheart.00181.2024. Epub 2024 Jul 19.
10
Fetal Cannabinoid Syndrome: Behavioral and Brain Alterations of the Offspring Exposed to Dronabinol during Gestation and Lactation.胎儿大麻素综合征：在妊娠和哺乳期暴露于屈大麻酚的后代的行为和大脑改变。
Int J Mol Sci. 2024 Jul 7;25(13):7453. doi: 10.3390/ijms25137453.
本文引用的文献
1
Preconception and prenatal cannabis use and the risk of behavioural and emotional problems in the offspring; a multi-informant prospective longitudinal study.孕前和产前使用大麻与后代行为和情绪问题的风险：一项多信息来源的前瞻性纵向研究。
Int J Epidemiol. 2019 Feb 1;48(1):287-296. doi: 10.1093/ije/dyy186.
2
Transfer of Inhaled Cannabis Into Human Breast Milk.吸入式大麻转移至人乳中。
Obstet Gynecol. 2018 May;131(5):783-788. doi: 10.1097/AOG.0000000000002575.
3
Successful Treatment of Cannabinoid Hyperemesis Syndrome with Topical Capsaicin.外用辣椒素成功治疗大麻素呕吐综合征
ACG Case Rep J. 2018 Jan 3;5:e3. doi: 10.14309/crj.2018.3. eCollection 2018.
4
Cannabinoid Hyperemesis Syndrome: Pathophysiology and Treatment in the Emergency Department.大麻素呕吐综合征：急诊科的病理生理学与治疗
J Emerg Med. 2018 Mar;54(3):354-363. doi: 10.1016/j.jemermed.2017.12.010. Epub 2018 Jan 5.
5
Committee Opinion No. 722: Marijuana Use During Pregnancy and Lactation.委员会意见第 722 号：妊娠期和哺乳期使用大麻。
Obstet Gynecol. 2017 Oct;130(4):e205-e209. doi: 10.1097/AOG.0000000000002354.
6
No. 349-Substance Use in Pregnancy.第349号——孕期物质使用
J Obstet Gynaecol Can. 2017 Oct;39(10):922-937.e2. doi: 10.1016/j.jogc.2017.04.028.
7
Cannabis use during pregnancy: Pharmacokinetics and effects on child development.孕期使用大麻：药代动力学和对儿童发育的影响。
Pharmacol Ther. 2018 Feb;182:133-151. doi: 10.1016/j.pharmthera.2017.08.014. Epub 2017 Aug 25.
8
Cannabinoid hyperemesis syndrome presentation to the emergency department: A two-year multicentre retrospective chart review in a major urban area.大麻素呕吐综合征在急诊科的表现：在一个主要城区的两年多中心回顾性图表审查。
CJEM. 2018 Jul;20(4):550-555. doi: 10.1017/cem.2017.381. Epub 2017 Aug 24.
9
Clinical Inquiry: What effects--if any--does marijuana use during pregnancy have on the fetus or child?临床探究：孕期使用大麻对胎儿或儿童有什么影响（如果有影响的话）？
J Fam Pract. 2017 Jul;66(7):462-466.
10
Pregnant Women's Current and Intended Cannabis Use in Relation to Their Views Toward Legalization and Knowledge of Potential Harm.孕妇当前及预期的大麻使用情况与其对大麻合法化的看法及潜在危害知识的关系。
J Addict Med. 2017 May/Jun;11(3):211-216. doi: 10.1097/ADM.0000000000000299.
Zotero 插件