光合作用研究中的合成生物学愿望清单。
A wish list for synthetic biology in photosynthesis research.
机构信息
Institute of Plant Physiology and Ecology and Center for Excellence for Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
Departments of Plant Biology and Crop Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA.
出版信息
J Exp Bot. 2020 Apr 6;71(7):2219-2225. doi: 10.1093/jxb/eraa075.
This perspective summarizes the presentations and discussions at the ' International Symposium on Synthetic Biology in Photosynthesis Research', which was held in Shanghai in 2018. Leveraging the current advanced understanding of photosynthetic systems, the symposium brain-stormed about the redesign and engineering of photosynthetic systems for translational goals and evaluated available new technologies/tools for synthetic biology as well as technological obstacles and new tools that would be needed to overcome them. Four major research areas for redesigning photosynthesis were identified: (i) mining natural variations of photosynthesis; (ii) coordinating photosynthesis with pathways utilizing photosynthate; (iii) reconstruction of highly efficient photosynthetic systems in non-host species; and (iv) development of new photosynthetic systems that do not exist in nature. To expedite photosynthesis synthetic biology research, an array of new technologies and community resources need to be developed, which include expanded modelling capacities, molecular engineering toolboxes, model species, and phenotyping tools.
本文总结了 2018 年在上海举行的“光合作用合成生物学国际研讨会”的报告和讨论。该研讨会利用当前对光合作用系统的深入了解，围绕着为转化目标重新设计和工程光合作用系统进行了头脑风暴，并评估了用于合成生物学的现有新技术/工具，以及克服这些技术障碍所需的新技术/工具。确定了重新设计光合作用的四个主要研究领域：（i）挖掘光合作用的自然变异；（ii）协调光合作用与利用光合作用产物的途径；（iii）在非宿主物种中重建高效光合作用系统；以及（iv）开发自然界中不存在的新的光合作用系统。为了加快光合作用合成生物学的研究，需要开发一系列新技术和社区资源，包括扩展的建模能力、分子工程工具包、模式物种和表型分析工具。
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