Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Department of Pediatric Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Arch Virol. 2020 Apr;165(4):963-966. doi: 10.1007/s00705-020-04547-0. Epub 2020 Feb 14.
Human parechoviruses (HPeV) of the species Parechovirus A are highly prevalent disease-causing pathogens in children worldwide. HPeVs are capable of causing severe disease in adults as well, but the prevalence in adults may be much lower. The aim of our present study was to determine the prevalence of HPeV in clinical samples from adults sent in for diagnostic procedures in a tertiary hospital in the Netherlands. From a total of 10,645 samples obtained from 6175 patients, 20 samples from 11 patients (0.18%) tested positive for HPeV by RT-PCR. Two patients were positive for HPeV-1, two for HPeV-3, and one for HPeV-6. Six HPeVs could not be typed. Eight of the 11 HPeV-positive patients were immunocompromised. Due to comorbidity, we were unable to attribute the patients' clinical symptoms to the HPeV infection. The HPeV prevalence in adults found in this study is low compared to HPeV prevalence in children. This may be largely explained by the high seropositivity rates in adults, although there could be other mechanisms involved.
人类肠道病毒（HPeV）属于肠道病毒 A 种，是全球儿童中高度流行的致病病原体。HPeV 也能在成人中引起严重疾病，但成人中的流行率可能低得多。我们目前的研究目的是确定在荷兰一家三级医院进行诊断程序的成人临床样本中 HPeV 的流行率。从 6175 名患者的总共 10645 个样本中，通过 RT-PCR 从 11 名患者的 20 个样本中检测到 20 个 HPeV 呈阳性（0.18%）。两名患者 HPeV-1 阳性，两名患者 HPeV-3 阳性，一名患者 HPeV-6 阳性。有 6 种 HPeV 无法分型。11 名 HPeV 阳性患者中有 8 名免疫功能低下。由于合并症，我们无法将患者的临床症状归因于 HPeV 感染。与儿童中的 HPeV 流行率相比，本研究中成人的 HPeV 流行率较低。这可能在很大程度上是由于成人的高血清阳性率所致，尽管可能涉及其他机制。
