Kieny M P, Blancou J, Lathe R, Pastoret P P, Soulebot J P, Desmettre P, Lecocq J P
Transgène, S.A. Strasbourg, France.
Rev Infect Dis. 1988 Nov-Dec;10 Suppl 4:S799-802. doi: 10.1093/clinids/10.supplement_4.s799.
Rabies is prevalent in most parts of the world. An extensive reservoir of the disease is present in the population of wild animals. The fox in particular is a major vector of the disease in North America and Europe. Although attempts to control rabies by vaccination of wild carnivores with attenuated rabies virus have met with some success, this approach remains controversial. The potential of a recombinant vaccinia virus expressing the rabies glycoprotein for the protection of foxes against rabies was examined. Both the parental (wild-type) and recombinant viruses were found to be innocuous to foxes. Inoculation of live recombinant virus via the subcutaneous, intradermal, or oral routes uniformly elicited high titers of neutralizing antibodies, and animals that received 10(8) plaque-forming units of the recombinant virus in bait resisted severe challenge with live rabies virus.
狂犬病在世界大部分地区都很普遍。野生动物群体中存在该疾病的广泛宿主。特别是狐狸，它是北美和欧洲该疾病的主要传播媒介。尽管通过用减毒狂犬病病毒对野生食肉动物进行疫苗接种来控制狂犬病的尝试取得了一些成功，但这种方法仍存在争议。研究了表达狂犬病糖蛋白的重组痘苗病毒保护狐狸免受狂犬病侵害的潜力。发现亲本（野生型）病毒和重组病毒对狐狸均无害。通过皮下、皮内或口服途径接种活重组病毒均能一致地引发高滴度的中和抗体，并且在诱饵中接受10⁸ 个重组病毒空斑形成单位的动物能够抵抗活狂犬病病毒的严重攻击。
