Brochier B M, Languet B, Blancou J, Kieny M P, Lecocq J P, Costy F, Desmettre P, Pastoret P P
Department of Virology and Immunology, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.
Vet Microbiol. 1988 Oct;18(2):103-8. doi: 10.1016/0378-1135(88)90055-7.
Thirteen fox cubs were orally administered 10(7.2) plaque-forming units of live vaccinia-rabies glycoprotein recombinant virus. On Day 28 post-vaccination, all but 1 cub had produced rabies virus antibodies. Twelve animals were intramuscularly inoculated with 10(3.2) mouse intracerebral LD50 of rabies virus suspension on Days 33 (5 foxes), 180 (4 foxes) or 360 (3 foxes) after vaccination. Eleven of them resisted rabies challenge. Unvaccinated foxes, either put in contact with 1 vaccinated animal or used as controls, died after challenge applied on Day 33. The absence of horizontal transmission of this vaccine strain and its innocuity to cubs were also demonstrated.
给13只狐狸幼崽口服10(7.2)个空斑形成单位的活痘苗-狂犬病糖蛋白重组病毒。接种疫苗后第28天，除1只幼崽外，其余所有幼崽均产生了狂犬病病毒抗体。在接种疫苗后的第33天（5只狐狸）、180天（4只狐狸）或360天（3只狐狸），给12只动物肌肉注射10(3.2)小鼠脑内半数致死量的狂犬病病毒悬液。其中11只抵抗了狂犬病攻击。未接种疫苗的狐狸，要么与1只接种疫苗的动物接触，要么用作对照，在第33天接受攻击后死亡。还证明了该疫苗株不存在水平传播且对幼崽无毒。
