Tolson N D, Charlton K M, Casey G A, Knowles M K, Rupprecht C E, Lawson K F, Campbell J B
Agriculture Canada, Animal Diseases Research Institute, Nepean, Ontario, Canada.
Arch Virol. 1988;102(3-4):297-301. doi: 10.1007/BF01310835.
Foxes were vaccinated orally (by bait), gastrically (by stomach tube) and by scarification with a vaccinia recombinant virus expressing the rabies glycoprotein. Neutralizing antibodies against rabies virus were detected at two weeks postvaccination in 8/8 foxes in the bait-fed group, in 3/6 foxes inoculated by stomach tube and in 2/2 of the scarified foxes. After challenge at three months postvaccination with street rabies virus, all foxes that had developed antibodies were protected. The high rate of seroconversion, high levels of antibodies, and resistance to challenge suggest that this recombinant virus might be a suitable vaccine for oral immunization of foxes against rabies.
狐狸通过口服（投喂诱饵）、胃内（通过胃管）以及用表达狂犬病糖蛋白的痘苗重组病毒划痕接种进行疫苗接种。在接种疫苗两周后，投喂诱饵组的8只狐狸中有8只、经胃管接种的6只狐狸中有3只以及划痕接种的2只狐狸中有2只检测到了抗狂犬病病毒的中和抗体。在接种疫苗三个月后用街狂犬病毒进行攻击后，所有产生抗体的狐狸都受到了保护。高血清转化率、高抗体水平以及对攻击的抵抗力表明，这种重组病毒可能是一种适合狐狸口服免疫狂犬病的疫苗。
