嗅球回路的可塑性。
Plasticity in olfactory bulb circuits.
机构信息
Neurobiology Section, Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Neurobiology Section, Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Curr Opin Neurobiol. 2020 Oct;64:17-23. doi: 10.1016/j.conb.2020.01.007. Epub 2020 Feb 13.
Abstract
Olfaction is crucial for animal survival and human well-being. The olfactory bulb is the obligatory input station for olfactory information. In contrast to the traditional view as a static relay station, recent evidence indicates that the olfactory bulb dynamically processes olfactory information in an experience-dependent and context-dependent manner. Here, we review recent studies on experience-dependent plasticity of the main circuit components within the olfactory bulb of rodents. We argue that the olfactory bulb plasticity allows optimal representations of behaviorally-relevant odors in the continuously changing olfactory environment.
摘要
嗅觉对于动物的生存和人类的福祉至关重要。嗅球是嗅觉信息的必经输入站。与传统观点认为嗅球是一个静态的中继站不同，最近的证据表明，嗅球以依赖经验和依赖情境的方式动态地处理嗅觉信息。在这里，我们回顾了最近关于啮齿动物嗅球主要回路成分的经验依赖性可塑性的研究。我们认为，嗅球的可塑性允许在不断变化的嗅觉环境中对与行为相关的气味进行最佳的表示。
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本文引用的文献
1
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Cereb Cortex. 2020 Mar 21;30(2):534-549. doi: 10.1093/cercor/bhz105.
2
Rapid task-dependent tuning of the mouse olfactory bulb.快速的任务相关调节对鼠类嗅觉球的影响。
Elife. 2019 Feb 6;8:e43558. doi: 10.7554/eLife.43558.
3
An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants.神经干细胞和嗅球成体神经发生的增加改善了对高度相似气味的辨别能力。
EMBO J. 2019 Mar 15;38(6). doi: 10.15252/embj.201798791. Epub 2019 Jan 14.
4
Single-Cell RNA-Seq of Mouse Olfactory Bulb Reveals Cellular Heterogeneity and Activity-Dependent Molecular Census of Adult-Born Neurons.单细胞 RNA 测序揭示了成年新生神经元的细胞异质性和活性依赖性分子普查。
Cell Rep. 2018 Dec 4;25(10):2689-2703.e3. doi: 10.1016/j.celrep.2018.11.034.
5
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Neuron. 2018 Jun 27;98(6):1214-1228.e5. doi: 10.1016/j.neuron.2018.05.016. Epub 2018 May 31.
6
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Elife. 2018 Mar 13;7:e33006. doi: 10.7554/eLife.33006.
7
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Elife. 2018 Feb 28;7:e34976. doi: 10.7554/eLife.34976.
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