McAdams Ian, Kenyon Hannah, Bourbeau Dennis, Damaser Margot S, Zorman Christian, Majerus Steve J A
Dept. of Biomedical Engineering, Lerner Research Institute.
Dept. of Electrical Engineering and Computer Science Case Western Reserve University Cleveland, Ohio, USA.
IEEE Biomed Circuits Syst Conf. 2018 Oct;2018. doi: 10.1109/BIOCAS.2018.8584729. Epub 2018 Dec 24.
The role of peripheral nerves in regulating major organ function in health and disease is not well understood. Elucidating the relationships between biomarkers and neural activity during conditions free form anesthesia is essential to advancing future investigations of autonomic organ control and improving precision for neuromodulation treatment approaches. Here we present a simple, customizable, off-the-shelf component sensor platform to meet research needs for studying different organs under conscious, free movement. The platform consists of a small, rechargeable coin-cell battery, an energy-harvesting IC, a low-power microcontroller, a low-power pressure transducer, customizable number of electrodes with a common anode, inductive recharge input, and OOK inductive transmission. A case study demonstrating a bladder implant for long-term monitoring is presented, utilizing a novel, non-hermetic encapsulation approach. The customized platform uses two sleep modes to minimize battery loading, exhibiting a maximum time-averaged current draw of 125 micro-amps during sensing and transmission, with a quiescent current draw of 95 nano-amps into the microcontroller.
外周神经在健康和疾病状态下调节主要器官功能的作用尚未得到充分理解。阐明在无麻醉状态下生物标志物与神经活动之间的关系对于推进未来自主器官控制的研究以及提高神经调节治疗方法的精准度至关重要。在此，我们展示了一个简单、可定制的现成组件传感器平台，以满足在清醒、自由活动状态下研究不同器官的研究需求。该平台由一个小型可充电纽扣电池、一个能量收集集成电路、一个低功耗微控制器、一个低功耗压力传感器、可定制数量的具有公共阳极的电极、感应充电输入和开关键控感应传输组成。本文介绍了一个利用新型非密封封装方法的膀胱植入物进行长期监测的案例研究。定制平台使用两种睡眠模式来最小化电池负载，在传感和传输过程中表现出的最大时间平均电流消耗为125微安，微控制器的静态电流消耗为95纳安。
