Mekbib Destaw B, Han Jiawei, Zhang Li, Fang Shan, Jiang Hongjie, Zhu Junming, Roe Anna W, Xu Dongrong
Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT), College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Brain Inj. 2020 Mar 20;34(4):456-465. doi: 10.1080/02699052.2020.1725126. Epub 2020 Feb 17.
Stroke is a major cause of life-long disability in adults, associated with poor quality of life. Virtual reality (VR)-based therapy systems are known to be helpful in improving motor functions following stroke, but recent clinical findings have not been included in the previous publications of meta-analysis studies. This meta-analysis was based on the available literature to evaluate the therapeutic potential of VR as compared to dose-matched conventional therapies (CT) in patients with stroke. We retrieved relevant articles in EMBASE, MEDLINE, PubMed, and Web of Science published between 2010 and February 2019. Peer-reviewed randomized controlled trials that compared VR with CT were included. A total of 27 studies met the inclusion criteria. The analysis indicated that the VR group showed statistically significant improvement in the recovery of UL function (Fugl-Meyer Upper Extremity [FM-UE]: n = 20 studies, Mean Difference [MD] = 3.84, = .01), activity (Box and Block Test [BBT]: n = 13, MD = 3.82, = .04), and participation (Motor Activity Log [MAL]: n = 6, MD = 0.8, = .0001) versus the control group. VR appears to be a promising therapeutic technology for UL motor rehabilitation in patients with stroke.
中风是成年人终身残疾的主要原因，与生活质量差有关。基于虚拟现实（VR）的治疗系统已知有助于改善中风后的运动功能，但最近的临床研究结果尚未纳入先前的荟萃分析研究出版物中。本荟萃分析基于现有文献，评估与剂量匹配的传统疗法（CT）相比，VR对中风患者的治疗潜力。我们检索了2010年至2019年2月期间在EMBASE、MEDLINE、PubMed和科学网发表的相关文章。纳入了比较VR与CT的同行评审随机对照试验。共有27项研究符合纳入标准。分析表明，与对照组相比，VR组在上肢功能恢复（Fugl-Meyer上肢[FM-UE]：n = 20项研究，平均差[MD] = 3.84，P = 0.01）、活动能力（箱块测试[BBT]：n = 13，MD = 3.82，P = 0.04）和参与度（运动活动日志[MAL]：n = 6，MD = 0.8，P = 0.0001）方面有统计学显著改善。VR似乎是中风患者上肢运动康复的一种有前景的治疗技术。
