Department of Neurology, Rigshospitalet, Juliane Maries Vej 28, 2100, Copenhagen, Denmark.
J Neurol. 2020 Jun;267(6):1679-1686. doi: 10.1007/s00415-020-09758-8. Epub 2020 Feb 17.
Physical inactivity is associated with lifestyle diseases and exercise of moderate intensity seems beneficial in DM1, but knowledge about physical activity and predictors of physical activity in individuals with myotonic dystrophy type 1 (DM1) is limited. The objective of this study is to assess physical activity and predictors of physical activity in individuals with DM1.
Sixty-seven adults with DM1 and 39 healthy adults were recruited. Physical activity was monitored by accelerometry and assessed using the International Physical Activity Questionnaire. Age, marital status, education, apathy, cognition, fatigue, and muscle strength were assessed as predictors of physical activity in DM1.
The individuals with DM1 were on average - 187 min (p < 0.00001) objectively and - 48% (p = 0.001) subjectively less physically active per week compared to healthy controls. Education was the only predictor of physical activity in DM1 (p = 0.02).
Individuals with DM1 are less physically active compared to healthy controls and only half of the patients fulfilled minimum requirements for recommended physical activity. Education is the only predictor of physical activity in DM1. Thus, enhancement of physical activity in individuals with DM1 might be suggested, and especially in the less educated individuals, but RCT studies are needed to guide exact recommendations.
身体活动不足与生活方式疾病有关，中等强度的运动似乎对 1 型糖尿病有益，但关于 1 型肌强直性营养不良（DM1）患者的身体活动和身体活动预测因素的知识有限。本研究的目的是评估 DM1 患者的身体活动和身体活动的预测因素。
招募了 67 名成年 DM1 患者和 39 名健康成年人。通过加速度计监测身体活动，并使用国际体力活动问卷进行评估。年龄、婚姻状况、教育程度、冷漠、认知、疲劳和肌肉力量被评估为 DM1 患者身体活动的预测因素。
与健康对照组相比，DM1 患者每周平均客观活动减少 187 分钟（p<0.00001），主观活动减少 48%（p=0.001）。教育是 DM1 患者身体活动的唯一预测因素（p=0.02）。
与健康对照组相比，DM1 患者的身体活动较少，只有一半的患者达到了推荐身体活动的最低要求。教育是 DM1 患者身体活动的唯一预测因素。因此，可能建议 DM1 患者增加身体活动，特别是在教育程度较低的患者中，但需要 RCT 研究来指导确切的建议。
