Treatment with 5 attenuates intestinal damage and inflammatory response in experimental colitis.

This study evaluated the effects of 5 on the intestinal mucosa and inflammatory response in experimental colitis. Colitis was induced by administration of 3.5% dextran sodium sulphate (DSS) solution for 7 days. Two periods of administration were performed: treatment (T) group, mice received only during disease induction (7 days); total treatment (TT) group, mice received for 10 days before and during disease induction. The probiotic effects on intestinal permeability, inflammatory infiltrate, histological analysis, cytokines, chemokines and sIgA were evaluated. administration in the T group showed reduction in intestinal permeability and lower IL-1β, myeloperoxidase, and eosinophil peroxidase levels compared to those in the colitis group (<0.05). administration in the TT group attenuated severe lesions in the colon and reduced eosinophil peroxidase level (<0.05). 5 treatment modality was more effective than total treatment and reduced the inflammatory response and its consequences on intestinal epithelium.