Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Xianyang 712100, China.
Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York 14850, United States.
J Agric Food Chem. 2020 Mar 11;68(10):3099-3111. doi: 10.1021/acs.jafc.9b07598. Epub 2020 Mar 2.
Sesamol, a lignan in sesame, possesses several bioactivities, such as antioxidation, anti-inflammation, and neuroprotective capability. In this study, the effects of sesamol on aging-caused cognitive defects are investigated. Twelve-month-old mice were treated with sesamol (0.1%, w/w) as dietary supplementation for 12 weeks. Behavioral tests revealed that sesamol improved aging-associated cognitive impairments. Sesamol decreased aging-induced oxidative stress via suppression of malondialdehyde production and increased antioxidant enzymes. Histological staining showed that sesamol treatment improved aging-induced neuronal damage and synaptic dysfunction in the hippocampus. Furthermore, sesamol significantly reduced aging-induced neuroinflammation by inhibiting the microglial overactivation and inflammatory cytokine expressions. Meanwhile, the accumulation of Aβ was reduced by sesamol treatment. Moreover, sesamol protected the gut barrier integrity and reduced LPS release, which was highly associated with its beneficial effects on behavioral and inflammatory changes. In conclusion, our findings indicated that the use of sesamol is feasible in the treatment of aging-related diseases.
芝麻酚是芝麻中的一种木脂素，具有多种生物活性，如抗氧化、抗炎和神经保护能力。在这项研究中，研究了芝麻酚对衰老引起的认知缺陷的影响。将 12 个月大的小鼠用芝麻酚（0.1%，w/w）作为饮食补充剂处理 12 周。行为测试显示，芝麻酚改善了与衰老相关的认知障碍。芝麻酚通过抑制丙二醛的产生和增加抗氧化酶来减少衰老引起的氧化应激。组织学染色显示，芝麻酚处理改善了海马区衰老引起的神经元损伤和突触功能障碍。此外，芝麻酚通过抑制小胶质细胞过度激活和炎症细胞因子表达显著减少衰老引起的神经炎症。同时，芝麻酚处理减少了 Aβ 的积累。此外，芝麻酚保护肠道屏障的完整性并减少 LPS 的释放，这与其对行为和炎症变化的有益影响密切相关。总之，我们的研究结果表明，使用芝麻酚治疗与衰老相关的疾病是可行的。
