闭环系统及其挑战，我们处于什么位置？
Where Do We Stand with Closed-Loop Systems and Their Challenges?
机构信息
Division of Endocrinology, Harold Schnitzer Diabetes Health Center, Oregon Health & Science University, Portland, Oregon.
出版信息
Diabetes Technol Ther. 2020 Jul;22(7):485-491. doi: 10.1089/dia.2019.0469. Epub 2020 May 22.
Abstract
Treatments for type 1 diabetes have advanced significantly over recent years. There are now multiple hybrid closed-loop systems commercially available and additional systems are in development. Challenges remain, however. This review outlines the recent advances in closed-loop systems and outlines the remaining challenges, including post-prandial hyperglycemia and exercise-related dysglycemia.
摘要
近年来，1 型糖尿病的治疗方法取得了显著进展。目前有多种混合闭环系统可供商业使用，还有更多的系统正在开发中。然而，挑战仍然存在。本文概述了闭环系统的最新进展，并概述了仍然存在的挑战，包括餐后高血糖和与运动相关的血糖异常。
相似文献
1
Where Do We Stand with Closed-Loop Systems and Their Challenges?闭环系统及其挑战，我们处于什么位置？
Diabetes Technol Ther. 2020 Jul;22(7):485-491. doi: 10.1089/dia.2019.0469. Epub 2020 May 22.
2
The Artificial Pancreas and Type 1 Diabetes.人工胰腺与 1 型糖尿病。
J Clin Endocrinol Metab. 2023 Jun 16;108(7):1614-1623. doi: 10.1210/clinem/dgad068.
3
Overnight closed-loop insulin delivery with model predictive control: assessment of hypoglycemia and hyperglycemia risk using simulation studies.采用模型预测控制的夜间闭环胰岛素输注：利用模拟研究评估低血糖和高血糖风险
J Diabetes Sci Technol. 2009 Sep 1;3(5):1109-20. doi: 10.1177/193229680900300514.
4
Use of Advanced Hybrid Closed-Loop System in a Patient with Pancreas Cancer.晚期混合闭环系统在一名胰腺癌患者中的应用。
Diabetes Technol Ther. 2022 Sep;24(9):675-676. doi: 10.1089/dia.2021.0560.
5
Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator - in silico evaluation under intra-day variability.使用自适应餐时大剂量计算器增强1型糖尿病的自动闭环血糖控制——日内变异性下的计算机模拟评估
Comput Methods Programs Biomed. 2017 Jul;146:125-131. doi: 10.1016/j.cmpb.2017.05.010. Epub 2017 Jun 1.
6
Development and Future of Automated Insulin Delivery (AID) Systems.自动胰岛素输送（AID）系统的发展与未来。
Diabetes Technol Ther. 2024 Mar;26(S3):1-6. doi: 10.1089/dia.2023.0467.
7
Fully Closed-Loop Multiple Model Probabilistic Predictive Controller Artificial Pancreas Performance in Adolescents and Adults in a Supervised Hotel Setting.闭环多模型概率预测控制器人工胰腺在监督下的宾馆环境中对青少年和成年人的性能。
Diabetes Technol Ther. 2018 May;20(5):335-343. doi: 10.1089/dia.2017.0424. Epub 2018 Apr 16.
8
Real world evidence of the efficacy of two hybrid closed loop systems for children and adults with type 1 diabetes with some clinical warnings.两种混合闭环系统对1型糖尿病儿童和成人疗效的真实世界证据及一些临床警示。
Diabetes Metab. 2022 Nov;48(6):101396. doi: 10.1016/j.diabet.2022.101396. Epub 2022 Oct 14.
9
Who needs an artificial pancreas? (？).谁需要人工胰腺？（？）。
J Diabetes. 2013 Sep;5(3):254-7. doi: 10.1111/1753-0407.12052. Epub 2013 May 29.
10
Comparing the technical reliability and insulin dosing of a "do-it-yourself artificial pancreas" with a commercial hybrid closed-loop system in a "shadow-mode" scenario: An exploratory study.在“影子模式”下比较“自制人工胰腺”与商用混合闭环系统的技术可靠性和胰岛素剂量：一项探索性研究。
Diabetes Obes Metab. 2023 Sep;25(9):2780-2783. doi: 10.1111/dom.15161. Epub 2023 Jun 13.
引用本文的文献
1
Revolutionizing Diabetes Management Through Nanotechnology-Driven Smart Systems.通过纳米技术驱动的智能系统革新糖尿病管理。
Pharmaceutics. 2025 Jun 13;17(6):777. doi: 10.3390/pharmaceutics17060777.
2
Applied body-fluid analysis by wearable devices.可穿戴设备在体液分析中的应用。
Nature. 2024 Dec;636(8041):57-68. doi: 10.1038/s41586-024-08249-4. Epub 2024 Dec 4.
3
Practical Guidance on Open Source and Commercial Automated Insulin Delivery Systems: A Guide for Healthcare Professionals Supporting People with Insulin-Requiring Diabetes.开源和商业自动胰岛素输送系统实用指南：面向支持胰岛素依赖型糖尿病患者的医疗保健专业人员的指南。
Diabetes Ther. 2022 Sep;13(9):1683-1699. doi: 10.1007/s13300-022-01299-9. Epub 2022 Aug 1.
本文引用的文献
1
Closed-loop insulin delivery in adults with type 1 diabetes in real-life conditions: a 12-week multicentre, open-label randomised controlled crossover trial.真实环境中 1 型糖尿病成人闭环胰岛素输注：为期 12 周的多中心、开放标签随机对照交叉试验。
Lancet Digit Health. 2019 May;1(1):e17-e25. doi: 10.1016/S2589-7500(19)30003-2. Epub 2019 May 2.
2
A Novel Dual-Hormone Insulin-and-Pramlintide Artificial Pancreas for Type 1 Diabetes: A Randomized Controlled Crossover Trial.一种新型的胰岛素-普兰林肽双重激素人工胰腺用于 1 型糖尿病：一项随机对照交叉试验。
Diabetes Care. 2020 Mar;43(3):597-606. doi: 10.2337/dc19-1922. Epub 2020 Jan 23.
3
Type 1 diabetes mellitus management in young children: implementation of current technologies.1 型糖尿病患儿管理：现有技术的应用。
Pediatr Res. 2020 Mar;87(4):624-629. doi: 10.1038/s41390-019-0665-4. Epub 2019 Nov 12.
4
Increased proportion of time in hybrid closed-loop "Auto Mode" is associated with improved glycaemic control for adolescent and young patients with adult type 1 diabetes using the MiniMed 670G insulin pump.对于使用美敦力670G胰岛素泵的成年1型糖尿病青少年和年轻患者，混合闭环“自动模式”下时间比例的增加与血糖控制的改善相关。
Diabetes Obes Metab. 2020 Apr;22(4):688-693. doi: 10.1111/dom.13912. Epub 2019 Dec 9.
5
Epidemiology of diabetes phenotypes and prevalent cardiovascular risk factors and diabetes complications in the National Health and Nutrition Examination Survey 2003-2014.2003-2014 年全国健康与营养调查中糖尿病表型及常见心血管风险因素和糖尿病并发症的流行病学。
Diabetes Res Clin Pract. 2019 Dec;158:107915. doi: 10.1016/j.diabres.2019.107915. Epub 2019 Nov 6.
6
Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes.1 型糖尿病闭环控制的 6 个月随机、多中心试验。
N Engl J Med. 2019 Oct 31;381(18):1707-1717. doi: 10.1056/NEJMoa1907863. Epub 2019 Oct 16.
7
Optimizing Postprandial Glucose Management in Adults With Insulin-Requiring Diabetes: Report and Recommendations.优化成人胰岛素依赖型糖尿病患者的餐后血糖管理：报告与建议
J Endocr Soc. 2019 Oct 7;3(10):1942-1957. doi: 10.1210/js.2019-00222. eCollection 2019 Oct 1.
8
Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions.在自由生活条件下，5 天内，1 型糖尿病成人、青少年和儿童使用 Omnipod 混合闭环系统的安全性和性能。
Diabetes Technol Ther. 2020 Mar;22(3):174-184. doi: 10.1089/dia.2019.0286. Epub 2019 Oct 29.
9
Faster Compared With Standard Insulin Aspart During Day-and-Night Fully Closed-Loop Insulin Therapy in Type 1 Diabetes: A Double-Blind Randomized Crossover Trial.在 1 型糖尿病的昼夜闭环胰岛素治疗中，与标准门冬胰岛素相比更快：一项双盲随机交叉试验。
Diabetes Care. 2020 Jan;43(1):29-36. doi: 10.2337/dc19-0895. Epub 2019 Oct 1.
10
Glucose Control in Adults with Type 1 Diabetes Using a Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study.使用美敦力原型增强型混合闭环系统控制 1 型糖尿病成人患者的血糖：一项可行性研究。
Diabetes Technol Ther. 2019 Sep;21(9):499-506. doi: 10.1089/dia.2019.0120. Epub 2019 Jul 2.
Zotero 插件