Key Lab. of Biomass Energy and Material, Jiangsu Province, Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing, 210042, China; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Province, Nanjing, 210042, China; Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, Beijing, 100714, China; National Engineering Lab. for Biomass Chemical Utilization, Nanjing, 210042, China.
Key Lab. of Biomass Energy and Material, Jiangsu Province, Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Nanjing, 210042, China.
Carbohydr Polym. 2020 Apr 15;234:115920. doi: 10.1016/j.carbpol.2020.115920. Epub 2020 Feb 3.
Vitamin C (VC) is an indispensable nutrient for human health. However, poor chemical stability in gastric environment restricts its full assimilation by intestine. It is important to construct a safe carrier that can protect VC from the gastric fluid and sustainably release it in intestine. Herein, we designed a novel polyelectrolyte complex (PEC) hydrogel through self-assembly of salecan and chitosan. PEC structure formed by electrostatic interactions was confirmed by FT-IR, XRD, XPS and TGA. Their swelling, morphology, rheology, cytocompatibility and biodegradation were well investigated. In particular, VC released in a controlled and pH-dependent manner. The release amount in simulated intestinal fluid (SIF) was significantly higher than simulated gastric fluid (SGF), and can be maintained at high level in blood after 6 h. Release mechanism agreed well with Ritger-Peppas model. The purpose of this study was to develop a smart nutrient delivery platform for targeted release of VC in intestinal condition.
维生素 C（VC）是人类健康不可或缺的营养物质。然而，其在胃环境中较差的化学稳定性限制了其在肠道中的充分吸收。构建一种安全的载体，使其能够保护 VC 免受胃液的侵害，并在肠道中持续释放，这一点非常重要。在此，我们通过沙莱糖和壳聚糖的自组装设计了一种新型聚电解质复合物（PEC）水凝胶。通过傅里叶变换红外光谱（FT-IR）、X 射线衍射（XRD）、X 射线光电子能谱（XPS）和热重分析（TGA）证实了 PEC 结构是通过静电相互作用形成的。对其溶胀、形态、流变学、细胞相容性和生物降解性进行了深入研究。特别地，VC 以受控和 pH 依赖性的方式释放。在模拟肠液（SIF）中的释放量明显高于模拟胃液（SGF），并且在 6 小时后可在血液中保持较高水平。释放机制与 Ritger-Peppas 模型吻合较好。本研究旨在开发一种智能营养传递平台，以实现 VC 在肠道条件下的靶向释放。
