Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University, College Station, Texas 77843-4235, USA.
Learn Mem. 2020 Feb 18;27(3):119-123. doi: 10.1101/lm.050377.119. Print 2020 Mar.
Signaled active avoidance (SAA) behavior requires the suppression of defensive reactions, such as freezing, that conflict with the avoidance response. The neural mechanisms of this inhibitory process are not well understood. Here, we demonstrate that ventromedial prefrontal cortex projections to the nucleus reuniens of the thalamus are recruited following SAA training to suppress freezing in rats. This projection may serve as a crucial common pathway for the inhibition of innate defensive reactions that interfere with proactive behavior, thus facilitating adaptive coping.
信号主动回避（SAA）行为需要抑制与回避反应冲突的防御反应，如冻结。这个抑制过程的神经机制还不是很清楚。在这里，我们证明了腹内侧前额叶皮层向丘脑连合核的投射在 SAA 训练后被招募，以抑制大鼠的冻结。这条投射可能是抑制干扰主动行为的先天防御反应的关键共同途径，从而促进适应性应对。
