Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China.
J Mater Chem B. 2019 Apr 7;7(13):2220-2225. doi: 10.1039/c8tb03147a. Epub 2019 Mar 1.
Peptide-based supramolecular hydrogels are promising scaffold materials and have been utilized in many fields. The mechanical properties of peptide hydrogels are usually enhanced by synthetic or natural polymers to expand their application scope. In this study, antioxidant supramolecular hydrogels based on feruloyl-modified peptide and glycol chitosan were fabricated via a mild laccase-mediated crosslinking reaction. A natural polysaccharide derivative, feruloyl glycol chitosan (GC-Fer), was used to enhance the mechanical properties of peptide hydrogels. Feruloyl groups were introduced into the gel matrix via covalent bonds, which endowed the hydrogels with inherent antioxidant properties. This was beneficial for their in vivo application via scavenging harmful free radicals existing in a cutaneous wound. Further in vivo experiments demonstrated that the feruloyl-containing antioxidant hydrogel can improve the cutaneous wound healing process. The regeneration process of mature epithelium and connective tissues was accelerated in a full-thickness skin defect model.
基于肽的超分子水凝胶是一种很有前途的支架材料，已被广泛应用于多个领域。通过合成或天然聚合物来增强肽水凝胶的机械性能，可以扩大其应用范围。本研究通过温和的漆酶介导的交联反应制备了基于阿魏酰修饰肽和乙二醇壳聚糖的抗氧化超分子水凝胶。使用天然多糖衍生物阿魏酰化乙二醇壳聚糖（GC-Fer）来增强肽水凝胶的机械性能。通过共价键将阿魏酰基团引入凝胶基质中，赋予水凝胶内在的抗氧化性能。这有利于通过清除皮肤创伤中存在的有害自由基，将其应用于体内。进一步的体内实验表明，含有阿魏酸的抗氧化水凝胶可以改善皮肤创伤的愈合过程。在全层皮肤缺损模型中，成熟上皮和结缔组织的再生过程得到了加速。
