Université de Lyon, INRAE, VetAgro Sup, UsC 1233 RS2GP, Marcy-l'Etoile, France.
FNLON (National federation for pest control), Angers, France.
PLoS One. 2020 Feb 19;15(2):e0228577. doi: 10.1371/journal.pone.0228577. eCollection 2020.
Knowledge on the possible sources of human leptospirosis, other than rats, is currently lacking. To assess the distribution pattern of exposure and infection by Leptospira serogroups in the two main semi-aquatic rodents of Western France, coypus (Myocastor coypus) and muskrats (Ondatra zibethicus), results of micro-agglutination testing and renal tissue PCR were used. In coypus, the apparent prevalence was 11% (n = 524, CI95% = [9% - 14%]), seroprevalence was 42% (n = 590, CI95% = [38% - 46%]), and the predominant serogroup was Australis (84%). In muskrats, the apparent prevalence was 33% (n = 274, CI95% = [27% - 39%]), seroprevalence was 57% (n = 305, CI95% = [52% - 63%]), and the predominant serogroup was Grippotyphosa (47%). Muskrats should therefore be considered an important source of Grippotyphosa infection in humans and domestic animals exposed in this part of France.
目前，人们对于人类钩端螺旋体病除了老鼠之外的其他可能传染源的了解还很缺乏。为了评估法国西部两种主要半水生啮齿动物（海狸鼠和水貂）中钩端螺旋体血清群的暴露和感染分布模式，使用了微凝集试验和肾脏组织 PCR 的检测结果。在海狸鼠中，显性感染率为 11%（n=524，95%置信区间[9%-14%]），血清阳性率为 42%（n=590，95%置信区间[38%-46%]），主要血清群为 Australis（84%）。在水貂中，显性感染率为 33%（n=274，95%置信区间[27%-39%]），血清阳性率为 57%（n=305，95%置信区间[52%-63%]），主要血清群为 Grippotyphosa（47%）。因此，水貂应该被认为是法国这一地区接触 Grippotyphosa 感染的人类和家养动物的重要传染源。
