中国人西藏人群肌少症的诊断参考值。

Department of Pathophysiology, Jinzhou Medical University, Jinzhou, 121001, China.

Biological Anthropology Institute, Jinzhou Medical University, Jinzhou, 121001, China.

Sci Rep. 2020 Feb 20;10(1):3067. doi: 10.1038/s41598-020-60027-0.

Sarcopenia is an age-associated disease characterized by loss of muscle mass and function, but the diagnostic cutoff values remain controversial. To investigate the diagnostic cutoff values and incidence of sarcopenia in a plateau population, the limb skeletal muscle mass, gait speed and grip strength of 2318 Tibetan adults were measured according to the criteria of the Asian Working Group for Sarcopenia. We found that the diagnostic reference values for sarcopenia in the high-altitude population were significantly lower than those in the plain population, and the incidences of sarcopenia in the high-altitude population over 60 years old were 17.2% in men and 36.0% in women, which were significantly higher than those in the plain population. Our study proposes reference values for the diagnosis of sarcopenia in Tibet. We suggest that the cutoff value for sarcopenia in the plateau population should be established based on altitude. Hypoxia may be an important risk factor for sarcopenia.

肌少症是一种与年龄相关的疾病，其特征是肌肉质量和功能的丧失，但诊断的截止值仍存在争议。为了研究高原人群肌少症的诊断截止值和发病率，根据亚洲肌少症工作组的标准，对 2318 名藏族成年人的四肢骨骼肌量、步态速度和握力进行了测量。我们发现，高原人群肌少症的诊断参考值明显低于平原人群，60 岁以上高原人群肌少症的发病率男性为 17.2%，女性为 36.0%，明显高于平原人群。本研究提出了西藏肌少症的诊断参考值。我们建议根据海拔高度确定高原人群肌少症的截止值。低氧可能是肌少症的一个重要危险因素。