Liggins Institute, University of Auckland, Auckland, New Zealand.
Waitemata District Health Board, Auckland, New Zealand.
J Perinatol. 2020 May;40(5):732-742. doi: 10.1038/s41372-020-0631-3. Epub 2020 Feb 20.
To compare rates of small- and large-for-gestational age (SGA and LGA) neonates using four different weight centiles, and to relate these classifications to neonatal morbidity.
Neonates born at 33-40 weeks' gestation in a multiethnic population were classified as SGA or LGA by population reference (Fenton), population standard (INTERGROWTH), fetal growth curves (WHO), and customized (GROW) centiles. Likelihood of composite morbidity was determined compared with a common appropriate-for-gestational age referent group.
Among 45,505 neonates, SGA and LGA rates varied up to threefold by different centiles. Those most likely to develop neonatal morbidity were SGA or LGA on both the population reference and an alternative centile. Customized centiles identified over twice as many at-risk SGA neonates.
Customized centiles were most useful in identifying neonates at increased risk of morbidity, and those that were small on both customized and population reference centiles were at the highest risk.
比较使用四种不同体重百分位数的小胎龄儿（SGA）和大胎龄儿（LGA）的发生率，并将这些分类与新生儿发病率相关联。
在一个多民族人群中，对 33-40 周龄出生的新生儿，按照人群参考（Fenton）、人群标准（INTERGROWTH）、胎儿生长曲线（WHO）和定制（GROW）百分位数进行 SGA 或 LGA 分类。通过与常见的适胎龄参考组比较，确定复合发病率的可能性。
在 45505 名新生儿中，不同百分位数的 SGA 和 LGA 发生率差异可达三倍。在人群参考和替代百分位数上，SGA 或 LGA 最有可能发生新生儿发病率。定制百分位数确定了两倍以上有风险的 SGA 新生儿。
定制百分位数最有助于识别发病率增加的新生儿，而在定制和人群参考百分位数上都较小的新生儿风险最高。
