Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Departamento de Análises Clínicas, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brazil.
J Ethnopharmacol. 2020 May 23;254:112666. doi: 10.1016/j.jep.2020.112666. Epub 2020 Feb 19.
The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus.
The aim of the study was to investigate the antidiabetic activity of aqueous extracts and fractions prepared from the bracts and flowers of Musa x paradisiaca in streptozotocin (STZ)-induced diabetic rats and to chemically characterize the extracts.
Standard aqueous extracts of the flowers, bracts, and their fractions were prepared and their chemical composition was determined tentatively by high-performance liquid chromatography coupled to diode-array detection and mass spectrometry (HPLC-DAD-MS). Changes in fasting glycemia and oral glucose tolerance were evaluated in STZ-induced diabetic rats (n = 8) treated with aqueous extracts of Musa x paradisiaca (200 mg/kg) for 20 days.
Chemical analyses detected 21 compounds and 17 metabolites were identified, among which were glycosylated and acetylated phenylpropanoids of p-coumaric acid and caffeic acid, as well as a glycosylated flavonol and anthocyanins. Following 15 days of treatment, the bract aqueous extracts and the methanolic fraction of the flower had significant effects on the glycemic profile after glucose load in diabetic rats as compared with the untreated diabetic group.
The results of the present study show the antidiabetic potential of extracts of the flowers and bracts of M. x paradisiaca.
芭蕉属植物的花序，俗称香蕉花或香蕉心，在传统医学中用于治疗糖尿病。
本研究旨在研究芭蕉属植物花和苞片的水提物及其馏分对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖活性，并对提取物进行化学表征。
制备了花、苞片及其馏分的标准水提取物，并通过高效液相色谱-二极管阵列检测-质谱联用（HPLC-DAD-MS）对其化学成分进行了初步鉴定。用 STZ 诱导的糖尿病大鼠（n = 8）评价水提物对禁食血糖和口服葡萄糖耐量的影响。
化学分析检测到 21 种化合物和 17 种代谢物，其中包括对香豆酸和咖啡酸的糖基化和乙酰化苯丙素类化合物，以及糖基化黄酮醇和花色苷。经过 15 天的治疗，与未治疗的糖尿病组相比，苞片水提物和花的甲醇馏分对糖尿病大鼠葡萄糖负荷后的血糖谱有显著影响。
本研究结果表明，芭蕉属植物花和苞片的提取物具有降血糖潜力。
