Garanina Anastasiia S, Naumenko Victor A, Nikitin Aleksey A, Myrovali Eirini, Petukhova Anna Y, Klimyuk Svetlana V, Nalench Yulia A, Ilyasov Artem R, Vodopyanov Stepan S, Erofeev Alexander S, Gorelkin Peter V, Angelakeris Makis, Savchenko Alexander G, Wiedwald Ulf, Majouga Dr Alexander G, Abakumov Maxim A
National University of Science and Technology «MISiS», Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
National University of Science and Technology «MISiS», Moscow, Russia; National Medical Research Center for Psychiatry and Narcology, Moscow, Russia.
Nanomedicine. 2020 Apr;25:102171. doi: 10.1016/j.nano.2020.102171. Epub 2020 Feb 18.
Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4T1 when heated to 43 °C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4T1 tumor growth without improving the overall survival. High-temperature MHT (>47 °C) resulted in complete 4T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antitumor therapy.
磁热疗（MHT）是一种很有前景的癌症治疗方法。然而，作为温度函数的系统MHT对治疗效果的表征几乎未被分析。在此，我们首先在两种小鼠肿瘤模型——乳腺癌（4T1）和结肠癌（CT26）中，对钴铁氧体纳米颗粒介导的MHT有效性进行了体外和体内的温度依赖性比较分析。体外的总体MHT杀伤能力随温度升高而增加，当加热到43°C时，CT26细胞比4T1细胞更敏感。与体外数据一致，这种加热在体内治愈了非转移性CT26肿瘤，而仅抑制了转移性4T1肿瘤的生长，并未改善总体生存率。高温MHT（>47°C）导致4T1原发性肿瘤完全清除，长期生存率为25 - 40%，重要的是，与手术切除相比，更有效地预防了转移。因此，必须为每个肿瘤单独定义特定的MHT温度，以确保抗肿瘤治疗成功。
