Department of Food Science, National Taiwan Ocean University, No.2, Peining Rd., Jhongjheng District, Keelung City, 20224, Taiwan.
Biomed Pharmacother. 2020 May;125:109992. doi: 10.1016/j.biopha.2020.109992. Epub 2020 Feb 25.
Oxidative stress is recognized as a common pathology that affects up to half of all men infertile. Fucoxanthin possesses antioxidant activity, and several investigators have reported anti-inflammatory action. This study extracted powder of Sargassum glaucescens by acetone to obtained fucoxanthin rich-brown algae extract (FXE). The objective of this study was to evaluate the ameliorative effects of fucoxanthin extract from Sargassum glaucescens on lipopolysaccharide-induced inflammation in RAW264.7 macrophage cells and its protective effects of against Cisplatin (CP)-induced reproductive damage in hamsters. Eighty male Syrian hamsters were injected with and without CP, then daily oral gavage with various concentrations of fucoxanthin for 5 days. Treatment with FXE reduced the level of reactive oxygen species and malondialdehyde in RAW 264.7 cells and the rats' testis as well as protective effects on mitochondrial membrane potential. The FXE administration also improved testosterone level and alpha-glucosidase activity. The sperm count also increased after treated with FXE, whereas sperm abnormality was reduced. Histopathological analysis showed that FXE successfully improved the seminiferous tubules morphology. According to these findings, fucoxanthin extract from Sargassum glaucescens can be used as an alternative for the treatment of testicular damage.
氧化应激被认为是一种常见的病理学，影响多达一半的不育男性。岩藻黄质具有抗氧化活性，一些研究人员已经报道了其抗炎作用。本研究通过丙酮从马尾藻中提取粉末，得到富含岩藻黄质的褐藻提取物(FXE)。本研究的目的是评估马尾藻岩藻黄质提取物对脂多糖诱导的 RAW264.7 巨噬细胞炎症的改善作用及其对顺铂(CP)诱导的仓鼠生殖损伤的保护作用。将 80 只雄性叙利亚仓鼠注射 CP 或不注射 CP，然后每天口服不同浓度的岩藻黄质 5 天。FXE 处理降低了 RAW 264.7 细胞和大鼠睾丸中活性氧和丙二醛的水平，以及对线粒体膜电位的保护作用。FXE 给药还改善了睾酮水平和α-葡萄糖苷酶活性。FXE 处理后精子计数增加，精子异常减少。组织病理学分析表明，FXE 成功改善了精小管的形态。根据这些发现，马尾藻岩藻黄质提取物可用作治疗睾丸损伤的替代药物。
