Institute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Nutrients. 2020 Feb 18;12(2):509. doi: 10.3390/nu12020509.
Osteoarthritis (OA) is a degenerative condition of joints, causing pain and swelling, and can be caused or worsened by trauma and obesity. The objectives of this study were to determine whether pain behaviour and progression of OA were increased in rats with trauma-induced OA fed dietary saturated fatty acids (SFA). Male Wistar rats were fed either a corn starch diet (C) or high-carbohydrate high-fat diet (H) with either 20% beef tallow or SFA (lauric (HLA), myristic (HMA), palmitic (HPA) or stearic (HSA) acids) for 16 weeks prior to and 8 weeks after excision of the medial meniscus of right knee joint to initiate OA when pain behaviour, glial activity, progression of knee OA, inflammatory mediators and signs of metabolic syndrome were assessed. Rats fed beef tallow, palmitic or stearic acids showed increased pain symptoms characterised by decreased hind paw/limb withdrawal thresholds and grip strengths and increased spinal astrogliosis and microgliosis compared to rats fed lauric or myristic acids. However, the severity of OA joint damage was unchanged by these dietary manipulations. We conclude that pain symptoms of trauma-induced OA in rats worsen with increased dietary beef tallow or palmitic or stearic acids, but improve with lauric or myristic acids, despite unchanged OA cartilage damage.
骨关节炎（OA）是一种关节退行性疾病，会导致疼痛和肿胀，并且可能由创伤和肥胖引起或加重。本研究的目的是确定创伤性 OA 大鼠在摄入饮食饱和脂肪酸（SFA）后，疼痛行为和 OA 进展是否会增加。雄性 Wistar 大鼠在切除右膝关节内侧半月板之前和之后的 16 周内分别喂食玉米淀粉饮食（C）或高碳水化合物高脂肪饮食（H），并用 20%的牛脂或 SFA（月桂酸（HLA）、肉豆蔻酸（HMA）、棕榈酸（HPA）或硬脂酸（HSA））喂养，以启动 OA，然后评估疼痛行为、神经胶质活性、膝关节 OA 进展、炎症介质和代谢综合征的迹象。与喂食月桂酸或肉豆蔻酸的大鼠相比，喂食牛脂、棕榈酸或硬脂酸的大鼠表现出更多的疼痛症状，特征为后爪/肢体退缩阈值和握力降低，以及脊髓星形胶质细胞和小胶质细胞增多。然而，这些饮食干预对 OA 关节损伤的严重程度没有影响。我们的结论是，尽管 OA 软骨损伤没有改变，但大鼠创伤性 OA 的疼痛症状会因饮食中增加牛脂或棕榈酸或硬脂酸而恶化，但会因摄入月桂酸或肉豆蔻酸而改善。
