Coordinating Centre for Health Alerts and Emergencies (CCAES), Directorate General of Public Health, Quality and Innovation. Ministry of Health, Madrid, Spain.
Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain; Epidemiology and Public Health Network of Biomedical Research Centre (CIBERESP), Spain.
Acta Trop. 2020 May;205:105402. doi: 10.1016/j.actatropica.2020.105402. Epub 2020 Feb 20.
On October 3rd 2018, dengue virus (DENV) infection was confirmed in three family members (symptoms onset between August 18th and 27th) without travel history outside of Spain. They had been together in the Autonomous Communities (AC) of Murcia and Andalusia. By the end of October, a second cluster of two dengue cases (symptoms onset on September 27th and 30th) was confirmed in the AC of Murcia. DENV type 1 sequence was identical to the first cluster, and the epidemiological link was a visit from a case of the first cluster to a fruit-farm neighboring the small village of residence of the second cluster. The entomological investigation found Aedes albopictus activity in this area although all mosquitoes were PCR-negative for DENV. This is the first autochthonous dengue outbreak identified in Spain. This outbreak highlights challenges to timely detect and respond to DENV transmission and opens questions on dengue dynamics in a non-endemic context.
2018 年 10 月 3 日，3 名家庭成员（症状发作日期在 8 月 18 日至 27 日之间）被确认感染登革热病毒（DENV），这些人没有离开过西班牙。他们一直在穆尔西亚和安达卢西亚自治区（AC）。到 10 月底，穆尔西亚自治区又确认了第二组两例登革热病例（症状发作日期为 9 月 27 日和 30 日）。DENV 1 型序列与第一组相同，流行病学联系是第一组的一名病例前往第二组居住的小村庄附近的一个水果农场。昆虫学调查发现，该地区存在白纹伊蚊的活动，尽管所有蚊子的 PCR 检测均为 DENV 阴性。这是西班牙首次确认的本地登革热疫情。此次疫情突显了及时发现和应对 DENV 传播的挑战，并对非流行地区的登革热动态提出了疑问。
