Dündar Mehmet Akif, Temiz Selami Aykut, Tunçez İsmail Hakkı, Emre Elif, Emre Sadettin, Dursun Recep
Necmettin Erbakan University Medical Faculty, Department of Ear Nose Throat.
Necmettin Erbakan University Medical Faculty, Department of Dermatology.
Dermatol Pract Concept. 2025 Apr 1;15(2):5014. doi: 10.5826/dpc.1502a5014.
Psoriasis, a chronic inflammatory dermatological condition, is marked by recurring periods of activity and quiescence. This persistent inflammation contributes to a range of associated health issues. The respiratory system relies on nasal mucociliary clearance as a fundamental defense mechanism. Mucociliary transport dysfunction is frequently observed in chronic inflammatory states.
We aimed to determine the relationship between psoriasis and concomitant clinical conditions and nasal mucociliary clearance time (NMCT).
We conducted a study to evaluate NMCTin 34 individuals diagnosed with psoriasis and a control group of 35 healthy individuals.
Our results revealed a statistically significant prolongation of NMCT in the psoriasis group (11.26 ± 2 minutes) compared to the control group (9.2 ± 1.85 minutes, P<0.001). Moreover, a positive correlation was identified between NMCT and both the duration of psoriasis and the Psoriasis Area and Severity Index (PASI). This suggests that impaired nasal mucociliary clearance in individuals with psoriasis, especially those with more severe disease, may elevate their vulnerability to infections of the sinuses and nasal passages.
This highlights the need to consider strategies for enhancing mucociliary function in this patient population.
银屑病是一种慢性炎症性皮肤病，其特点是病情反复出现活动期和静止期。这种持续的炎症会引发一系列相关的健康问题。呼吸系统依赖鼻黏液纤毛清除作为一种基本的防御机制。黏液纤毛运输功能障碍在慢性炎症状态中经常出现。
我们旨在确定银屑病与伴随的临床状况以及鼻黏液纤毛清除时间（NMCT）之间的关系。
我们进行了一项研究，以评估34名被诊断为银屑病的个体和35名健康个体组成的对照组的鼻黏液纤毛清除时间。
我们的结果显示，与对照组（9.2±1.85分钟，P<0.001）相比，银屑病组的鼻黏液纤毛清除时间在统计学上显著延长（11.26±2分钟）。此外，鼻黏液纤毛清除时间与银屑病病程以及银屑病面积和严重程度指数（PASI）之间均呈正相关。这表明银屑病患者，尤其是病情较严重的患者，其鼻黏液纤毛清除功能受损可能会增加他们鼻窦和鼻腔感染的易感性。
这突出了需要考虑针对该患者群体增强黏液纤毛功能的策略。
