Seto F
Zoology Department, University of Oklahoma, Norman 73019.
Dev Comp Immunol. 1988 Fall;12(4):843-54. doi: 10.1016/0145-305x(88)90058-4.
Immunization with mouse erythrocytes (MRBC) elicited transient splenic enlargement as well as PFC formation in immunocompetent 7, 10, and 14 day chicks. An early enlargement within two days was followed by a decline and a second enlargement by day six. Only the early enlargement was observed when MRBC or Percoll was administered to neonatal chicks and late embryos. No significant splenomegaly was observed following cell transfer of bone marrow, spleen, leucocyte, thymocyte or bursal cell suspensions from B haplotype-compatible donors. During the adoptive immune response in embryo hosts, a minor early peak was observed that was followed by an elevated or progressive increase in spleen size. The data suggest that the early splenic response reflects primarily RES-vascular activity and the later enlargement is the consequence of immune proliferation.
用小鼠红细胞（MRBC）对免疫功能正常的7日龄、10日龄和14日龄雏鸡进行免疫接种，可引起脾脏短暂肿大以及形成空斑形成细胞（PFC）。在两天内出现早期肿大，随后下降，到第六天出现第二次肿大。当将MRBC或 Percoll 给予新生雏鸡和晚期胚胎时，仅观察到早期肿大。从B单倍型相容供体转移骨髓、脾脏、白细胞、胸腺细胞或法氏囊细胞悬液后，未观察到明显的脾肿大。在胚胎宿主的过继免疫反应过程中，观察到一个较小的早期峰值，随后脾脏大小升高或逐渐增加。数据表明，早期脾脏反应主要反映网状内皮系统-血管活性，而后期肿大是免疫增殖的结果。
