School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
Chem Commun (Camb). 2020 Mar 25;56(24):3504-3507. doi: 10.1039/c9cc08972a. Epub 2020 Feb 26.
Nanoparticle tracers with small sizes and large magnetization are critical for biomedical imaging and especially for magnetic particle imaging (MPI). Small size is important for accessing future intracellular and neurological in vivo applications Here, we show <15 nm nanoparticles made of zero valent iron cores, iron oxide shells and coated with a strongly binding brush co-polymer are effective MPI tracers. The small nanoparticle cores create a hydrodynamic diameter that is half of the state-of-the-art iron oxide tracers while the strongly magnetic zero valent iron maintains similar MPI signal magnitude and resolution.
对于生物医学成像，特别是对于磁性粒子成像（MPI）来说，具有小尺寸和大磁化率的纳米颗粒示踪剂是至关重要的。小尺寸对于未来的细胞内和神经内体应用至关重要。在这里，我们展示了由零价铁核、氧化铁壳组成的<15nm 纳米颗粒，并涂覆有强结合刷共聚物，这些纳米颗粒是有效的 MPI 示踪剂。小的纳米颗粒核心使其水动力直径减小到现有氧化铁示踪剂的一半，而强磁性的零价铁则保持类似的 MPI 信号幅度和分辨率。
