Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", 80131 Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Int J Environ Res Public Health. 2020 Feb 24;17(4):1441. doi: 10.3390/ijerph17041441.
: Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. : We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. : Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa risk, improved PCa-related survival, improved functional outcomes, and reduced ADT-related adverse events.
: 前列腺癌（PCa）是 65 岁以上男性的常见病。对于有风险或被诊断患有 PCa 的患者，体力活动（PA）的作用是一个不断发展的问题。我们旨在总结关于 PA 对 PCa 病理生理学和临床结果影响的现有证据。 : 我们进行了叙述性综述。总结了 PA 在老年患者中的作用，包括在 PCa 生物学、流行病学、肿瘤学和功能结果方面，以及在雄激素剥夺治疗（ADT）结果方面的作用。 : 假设解释 PA 在前列腺癌发生中的益处的潜在病理生理学途径包括循环胰岛素样生长因子-1（IGF-1）水平、氧化应激、全身炎症、性激素和肌因子。临床上，新出现的证据支持 PA 与降低 PCa 风险、改善与 PCa 相关的生存、改善功能结果和减少 ADT 相关不良事件相关的假设。
