Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):657-664. doi: 10.1080/14756366.2020.1733547.
Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. We wanted to investigate the effect of the daily intake of alkaline water on the molecular hallmark of aging and the anti-oxidant response. We watered a mouse model of aging with or without alkaline supplementation. After 10 months, we obtained the blood, the bone marrow and the ovaries from both groups. In the blood, we measured the levels of ROS, SOD-1, GSH, and the telomerase activity and analysed the bone marrow and the ovaries for the telomeres length. We found reduced ROS levels and increased SOD-1, GSH, telomerase activity and telomeres length in alkaline supplemented mice. We show here that watering by using alkaline water supplementation highly improves aging at the molecular level.
端粒长度和端粒酶活性目前被认为是衰老的分子标志。水是我们身体的主要需求，水应该是碱性的。最近的报告表明，衰老与水摄入量减少有关。我们想研究每天摄入碱性水对衰老的分子标志和抗氧化反应的影响。我们用或不用碱性补充物给衰老的小鼠模型浇水。10 个月后，我们从两组中获得了血液、骨髓和卵巢。在血液中，我们测量了 ROS、SOD-1、GSH 的水平和端粒酶活性，并分析了骨髓和卵巢中的端粒长度。我们发现碱性补充组的 ROS 水平降低，SOD-1、GSH、端粒酶活性和端粒长度增加。我们在这里表明，使用碱性水补充物浇水可以极大地改善衰老的分子水平。
