Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Antimicrob Resist Infect Control. 2020 Feb 27;9(1):41. doi: 10.1186/s13756-020-0700-6.
Nasal colonization of Staphylococcus aureus is a risk factor for the pathogen transmission and the development of infections. Limited information is available on the prevalence and molecular characteristics of S. aureus colonization in pediatric intensive care unit (ICU) patients.
A cross-sectional, island-wide study was conducted in 2011. Nasal swabs were collected from pediatric ICU patients at six tertiary hospitals in Taiwan.
Of 114 patients enrolled in total, nasal colonization of S. arueus was detected in 30 (26.3%) of them, among whom 20 (17.5%) with methicillin-resistant S. arueus (MRSA). The ST59/SCCmec IV and V clones were most common and accounted for 45% of MRSA isolates, followed by ST239/SCCmec III (25%) and ST45/SCCmec IV (20%) clones. Three ST59 MRSA isolates carried the Panton-Valentine Leukocidin genes.
The results indicated a high prevalence of S. arueus and MRSA nasal colonization among pediatric ICU patients in Taiwan. Identification of epidemic clones warrants the implement of infection control measures to reduce colonization and prevent the dissemination of MRSA in hospitals.
金黄色葡萄球菌（S. aureus）鼻腔定植是病原体传播和感染发展的危险因素。有关儿科重症监护病房（PICU）患者金黄色葡萄球菌定植的流行情况和分子特征的信息有限。
2011 年进行了一项横断面、全岛范围的研究。从台湾六家三甲医院的儿科 ICU 患者中采集鼻拭子。
在总共纳入的 114 名患者中，有 30 名（26.3%）检测到金黄色葡萄球菌定植，其中 20 名（17.5%）为耐甲氧西林金黄色葡萄球菌（MRSA）。ST59/SCCmec IV 和 V 克隆最为常见，占 MRSA 分离株的 45%，其次是 ST239/SCCmec III（25%）和 ST45/SCCmec IV（20%）克隆。3 株 ST59 MRSA 分离株携带杀白细胞素基因。
研究结果表明，台湾儿科 ICU 患者金黄色葡萄球菌和 MRSA 鼻腔定植率较高。鉴定流行克隆需要实施感染控制措施，以减少定植并防止 MRSA 在医院内传播。
