Nouri Mehran, Nasr-Esfahani Mohammad Hossein, Tarrahi Mohammad Javad, Amani Reza
Students' Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Centre, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Int J Fertil Steril. 2020 Apr;14(1):17-22. doi: 10.22074/ijfs.2020.5888. Epub 2020 Feb 24.
Infertility is a major worldwide problem which is caused by several factors such as environmental, physiological, and genetic conditions. Lycopene is considered to be one of the most important antioxidants that can contribute to reducing or preventing the psychological damage that leads to infertility. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on depression, anxiety and stress scales and quality of life in infertile men.
In this randomized clinical trial, 44 infertile men with oligozoospermia were randomly divided into the following two groups: the experimental group was supplemented with 25 mg lycopene, once per day for 12 weeks, and the control group received a placebo, for 12 weeks. Anthropometric and dietary data, physical activity, mood status, including depression, anxiety, stress, and quality of life scores were recorded pre- and post-intervention. Depression, anxiety and stress were assessed using a 21-item questionnaire (DASS-21) and quality of life was examined using the WHO 26-qustion questionnaire (WHOQOL).
The baseline age and body mass index (BMI) were not significantly different between the two groups (age: 31.89 ± 2.51 and 32.15 ± 2.16 years old for intervention and placebo, respectively; P=0.732 and BMI: 27.20 ± 1.68 and 26.53 ± 1.53; for intervention and placebo, respectively; P=0.206). There were no significant differences in depression, anxiety and stress values between the two groups; however, depression score significantly decreased in both groups compared to the baseline levels (P=0.028 and P=0.031). No significant differences were observed in four domains of quality of life, except for psychological domain that was improved in the lycopene group compared to the baseline values (P=0.049).
Short term supplementation of lycopene had no effect on mood status and quality of life, except for psychological status in infertile men (Registration number: IRCT20171105037249N1).
不孕不育是一个全球性的重大问题，由环境、生理和遗传等多种因素引起。番茄红素被认为是最重要的抗氧化剂之一，有助于减少或预防导致不孕不育的心理损伤。因此，本研究旨在评估补充番茄红素对不育男性抑郁、焦虑和压力量表以及生活质量的影响。
在这项随机临床试验中，44名少精子症不育男性被随机分为以下两组：实验组每天补充25毫克番茄红素，共12周，对照组服用安慰剂，为期12周。记录干预前后的人体测量和饮食数据、身体活动、情绪状态，包括抑郁、焦虑、压力和生活质量得分。使用21项问卷（DASS - 21）评估抑郁、焦虑和压力，并使用世界卫生组织26题问卷（WHOQOL）检查生活质量。
两组的基线年龄和体重指数（BMI）无显著差异（干预组和安慰剂组的年龄分别为31.89±2.51岁和32.15±2.16岁；P = 0.732；BMI分别为27.20±1.68和26.53±1.53；干预组和安慰剂组；P = 0.206）。两组之间的抑郁、焦虑和压力值无显著差异；然而，与基线水平相比，两组的抑郁评分均显著降低（P = 0.028和P = 0.031）。生活质量的四个领域未观察到显著差异，但与基线值相比，番茄红素组的心理领域有所改善（P = 0.049）。
短期补充番茄红素对不育男性的情绪状态和生活质量没有影响，但对心理状态有影响（注册号：IRCT201711050372并49N1）。
