Martin A, Lachmann P J
Clin Exp Immunol. 1977 Jan;27(1):13-22.
It has been observed that when serum C6 is measured by the haemolytic radial diffusion technique a heat labile factor limits the size of the haemolytic rings. This reduction is haemolysis has been shown to be due to alternative pathway activation of C6 in the agarose plate; and that the heat labile factor is Factor B of the alternative pathway. This phenomenon is of practical importance when assaying for C6; however, it does not explain the observations of a C6 inactivator reported by Nelson & Biro (1968).
据观察，当采用溶血放射状扩散技术测定血清C6时，一种热不稳定因子会限制溶血环的大小。溶血的这种减少已被证明是由于琼脂糖平板中C6的替代途径激活所致；并且这种热不稳定因子是替代途径的B因子。在检测C6时，这一现象具有实际重要性；然而，它并不能解释Nelson和Biro（1968年）报道的C6灭活剂的观察结果。
